Cholesterol is an essential substance produced by the liver and present in most cells of the body. Transported around by lipoproteins, it is necessary for a number of bodily functions, such as forming cell membranes, producing hormones like estrogen, testosterone and adrenal hormones, aiding metabolism and helping to create bile acids that aid digestion and nutrient absorption.

Cholest2Care

This unique, potent, and effective formula is excellent for supporting normal, healthy cholesterol levels.  This formula contains organic concentrated red yeast rice along with supportive nutrients which makes this formula extremely effective.  Red Yeast Rice (Monascus purpureus) is a fermented rice product that has been used in Traditional Chinese Medicine since the Tang Dynasty. Our Red Yeast Rice is USDA certified organic and is exclusively grown and processed in the US.  It is non GMO, clinical strength, and lab tested. ‡

Manufactured in a US FDA inspected facility.  GMP Compliant.   Purity and Potency Guaranteed!   We use the highest quality raw materials available. Testing is done at various stages of production.

Benefits:

• Helps support healthy total cholesterol levels.
• Helps support healthy triglyceride levels.
• May improve vascular system function.
• Supports healthy heart function after non-fatal myocardial infarction.
• May be helpful for patients who can’t tolerate statins.
• May support healthy arteries.
• Supports healthy low-density lipoprotein (LDL) and very low-density lipoprotein (VLDL) levels.

All IOH Nutrition Formulas Meet or Exceed cGMP Quality Standards. *These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure, or prevent any disease.

Cholest2Care Dosage: Take 1– 3 capsules at dinnertime or bedtime. Start with the lowest dose and assess every 3 months.

Ingredients:

• Red Yeast Rice: Organic and Standardized. Concentrated and potent. Tested for Citrinin.
• Alpha Lipoic Acid: Supports healthy cholesterol metabolism
• Guggul: Has shown to support healthy levels of cholesterol, triglyceride, low-density lipoprotein (LDL) and very low -density lipoprotein (VLDL)
• Policosinol: A low dose supports a healthy cholesterol profile.
• Coenzyme Q10: Supports heart health.

References:

1. Peng, D., Fong, A., & van Pelt, A. (2017). the effects of red yeast Rice supplementation on cholesterol levels in adults. AJN The American Journal of Nursing, 117 (8), 46-54.

2. Nguyen, T., Karl, M., &Santini, A. (2017). Red yeast rice. Foods, 6(3), 19.

3. Patel S. (2016). Functional food red yeast rice (RYR) for metabolic syndrome amelioration: a review on pros and cons. World journal of microbiology & biotechnology, 32(5), 87. doi:10.1007/s11274-016-2035-2

4. Lu, Z., Kou, W., Du, B., Wu, Y., Zhao, S., Brusco, O. A., ...& Chinese Coronary Secondary Prevention Study Group. (2008). Effect of Xuezhikang, an extract from red yeast Chinese rice, on coronary events in a Chinese population with previous myocardial infarction. The American journal of cardiology, 101(12), 1689-1693.

5. Burke F. M. (2015). Red yeast rice for the treatment of dyslipidemia. Current atherosclerosis reports, 17(4), 495. doi:10.1007/s11883-015-0495-8

6. Gerards, M. C., Terlou, R. J., Yu, H., Koks, C. H., &Gerdes, V. E. (2015). Traditional Chinese lipid-lowering agent red yeast rice results in significant LDL reduction but safety is uncertain - a systematic review and meta-analysis. Atherosclerosis, 240(2), 415–423. doi:10.1016/j.atherosclerosis.2015.04.004

7. Amom, Z., Zakaria, Z., Mohamed, J., Azlan, A., Bahari, H., TaufikHidayatBaharuldin, M., … Kamal Nik Hassan, M. (2008). Lipid lowering effect of antioxidant alphalipoic Acid in experimental atherosclerosis. Journal of clinical biochemistry and nutrition, 43(2), 88–94. doi:10.3164/jcbn.2008051

8. Harding, S. V., Rideout, T. C., & Jones, P. J. (2012). Evidence for using alpha-lipoic acid in reducing lipoprotein and inflammatory related atherosclerotic risk. Journal of dietary supplements, 9(2), 116–127. doi:10.3109/19390211.2012.683136

9. Das, S., Datta, A., Bagchi, C., Chakraborty, S., Mitra, A., &Tripathi, S. K. (2016). A Comparative Study of Lipid-Lowering Effects of Guggul and Atorvastatin Monotherapy in Comparison to Their Combination in High Cholesterol Diet-Induced Hyperlipidemia in Rabbits. Journal of dietary supplements, 13(5), 495–504. doi:10.3109/19390211.2015.1118654

10. Castaño, G., Mas, R., Fernández, L., Illnait, J., Gámez, R., & Alvarez, E. (2001). Effects of policosanol 20 versus 40 mg/day in the treatment of patients with type II hypercholesterolemia: a 6-month double-blind study. International journal of clinical pharmacology research, 21(1), 43–57.

‡ These statements have not been evaluated by the FDA. These products are not intended to diagnose, treat, cure or prevent any disease.

GlucoLipid

This unique formula combines three herbal ingredients to support healthy triglyceride, cholesterol, and blood sugar levels.‡

Benefits:

• Supports Healthy Cardiovascular System.
• Supports Healthy Blood Sugar Levels.
• Supports Healthy Triglyceride Levels.
• Supports Healthy HDL Levels.
• Supports Healthy Cholesterol and may reduce urinary mevalonate.
• Supports healthy liver function by reduction of TNF-α and CRP.
• Derived from the fruit juice of Citrus Bergamia Rissoet Poit
• Grown in the Calabria region of Italy
• Standardized to contain 11-19% bergamot flavanones

This Herbal Phytosome gives 7 times better absorption versus the herbal extract alone.

Mode of Action.

1. Inhibiting HMG‐CoA Reductase: is an enzyme linked to the liver’s cholesterol production. Melitidine and Brutieridine inhibit the liver’s ability to produce LDL, resulting in reduced cholesterol levels in liver cells.

2. Inhibiting Phosphodiesterases PDEs. Flavonoids in this formula mediate their beneficial effects on lipid and glucose homeostasis by PDE4 and PDE3B modulation. PDE4 plays a critical role in cAMP which regulates energy metabolism and glucose metabolism. PDE3B is crucial for cholesterol metabolism.

3. Activating AMPK can help prevent abdominal fat accumulation, help regulate glucose tolerance, help normalize liver markers, and reduce oxidative stress and inflammation in the liver and heart.

CoQ10 Ubiquinol

CoQ10 is extremely difficult to absorb, so it is critical to take it in this high-absorption form.  Note that absorption is enhanced by taking this formula with healthy fats such as eggs and olive oil.  Our CoQ10 also increases benefits by including mixed carotenoids and mixed tocopherols, both heart-health enhancing ingredients.  CoQ10 supports good heart health and also supports healthy gums. ‡

Since the discovery of CoQ10, facts about its clinical value have lead many to use this product. The proof of its benefits for human health are obvious. Scientific research has established that CoQ10 is one of the most useful natural supplements on the market today. Clinical results have also shown that CoQ10 helps as an adjunct therapy for those taking certain cholesterol lowering medications.

Why Take CoQ10?

As we age, our body produces less CoQ10. This trend leaves our body vulnerable to a CoQ10 deficiency.

Benefits: 

• Supports the heart, immune system & brain health
• Helps increase overall energy levels.
• Helpful while on cholesterol medications.
• Helps support the immune system.
• Aids in increased cellular energy production.
• Supports heart health Why Use OUR CoQ10?
• The unique blend of ingredients in this formula makes absorption much greater than that of encapsulated dry CoQ10 powder.
• 83% of those taking this formula had an increase in energy vs only 30% of those taking CoQ10 capsules.

This formula also contains natural carotenoids, natural mixed tocopherols & rice bran oil. These ingredients help to increase the absorption of the CoQ10 but also have supportive and beneficial effects of their own.

These additional ingredients are far superior compared to most CoQ10 formulas on the market. Many formulations utilize soy or other oils that are not as supportive or healthy as the mixed tocopherols or natural beta carotene.

*These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure, or prevent any disease.

Manufactured in a US FDA inspected facility.  GMP Compliant.   Purity and Potency Guaranteed!   We use the highest quality raw materials available. Testing is done at various stages of production. All IOH Nutrition Formulas Meet or Exceed cGMP Quality Standards. 

CoQ10 Ultra High Absorption Dosage:

Take 1 softgel 1-2 times a day with meals or as directed by your health care practitioner. If the response needed is inadequate after 1-2 weeks, you may increase the dosage to 2 gelcaps per dose .

60 Soft Gels

Note: Some find CoQ10 to be energizing so taking it in the evening may disturb some individuals sleep. 

References:

1. Bertilli, A. , Ronca, G. Carnitine and Coenzyme Q: Biochemical Properties and Functions, Synergism and Complementary Action. Int. Jour. Tiss. Reac., 12 (3): 183-186, 1990.

2. Bliznakov, Emile G., Coenzyme Q, the Immune System and Aging. Biomedical and Clinical Aspects of Coenzyme Q,

3: 311-323, 1981. 3. Conte, A. et. al., Protection of Adenylate Pool and Energy Charge by L-Carnitine and Coenzyme Q during Energy Depletion in Rat Heart Slices. Int. J.Tissue Reac.,12(3): 187-191, 1990.

4. Folkers, Karl et. al., Activities of Vitamin Q10 in Animal Models and a Serious Deficiency in Patients with Cancer. Biochem. Biophys. Res. Comm., 234(2): 296-299, 1997.

5. Folkers, Karl, Relationships between Coenzyme Q and Vitamin E. AJCN, 27: 1026-1034, 1974.

6. Folkers, Karl et. al., A One Year Bioavailability Study of Coenzyme Q10 with 3 Months Withdrawal Period. Molec. Aspects Med., 15: S281-S285, 1994.

7. Folkers, Karl et. al., Biochemical Deficiencies of Coenzyme Q10 in HIV-Infection and Exploratory Treatment. Austin , Texas, 1988.

8. Folkers, Karl, Relevance of the Biosynthesis of Coenzyme Q10 and of the Four Bases of DNA as a Rationale for the Molecular Causes of Cancer and a Therapy. Biochem. Biophys. Res. Comm., 224: 358-361, 1996.

9. Folkers, Karl and Simonsen, Rodney, Two Successful Double-blind Trials with Coenzyme Q10 (Vitamin Q10) on Muscular Dystrophies and Neurogenic Atrophies. Biochimica et Biophysica Acta, 1271: 281-286, 1995.

10. Folkers, K., and Langsjoen, Per H. et. al., Pronounced Increase of Survival of Patients with Cardiomyopathy when Treated with Coenzyme Q10 and Conventional Therapy. Int. J. Tiss. Reac., 12(3):163-168, 1990.

11. Hogenauer, G. et. al., The Macrophage Activating Potential of Ubiquinones. Biomedical and Clinical Aspects of Coenzyme Q, 3: 325-334, 1981.

12. Iwamoto, Y., Folkers, K., Deficiency of CoQ10 in Hypertensive Rats and Reduction of Deficiency by Treatment with Coenzyme Q10. Biochem. Biophys. Res. Comm. v58 n3: 743-748, 1974.

13. Judy, W.V. et. al., Regression of Prostate Cancer and Plasma Specific Antigens (PSA) in Patients on Treatment with CoQ10. Conference of the International Coenzyme Q10 Association, Abstr. 143, 1998.

14. Judy, W.V. et. al., Dose Related Effectiveness of Coenzyme Q10 in the Treatment of Chronic Fatigue. Conference of the International Coenzyme Q10 Association, Abstr. 86, 1998.

15. Kaikkonen, Jari et. al., Effect of Oral Coenzyme Q10 Supplementation on the Oxidation and Resistance of Human VLDL+LDL Fraction: Absorption and Antioxidative Properties of Oil and Granule-Based Preparations. Free Radical Biology & Medicine, 22 (7): 1195-1202, 1997.

16. Kamikawa, Tadashi et. al., Effects of Coenzyme Q10 on Exercise Tolerance in Chronic Stable Angina Pectoris. Am. J. Cardiol., 56 (4): 247- 251, 1985.

17. Langsjoen, Per H. et. al., A Six-Year Clinical Study of Therapy of Cardiomyopathy with Coenzyme Q10. Int. J. Tiss. Reac., 12 (3):169-171, 1990.

18. Manzoli, U. et. al., Coenzyme Q10 in Dilated Cardiomyopathy. Int. J. Tiss. Reac., 12(3): 173-178, 1990.

19. Morisco, C. et. al., Effect of Coenzyme Q10 Therapy in Patients with Congestive Heart Failure: A Long-term Multicenter Randomized Study. Clin. Invest., 71: S134-S136, 1993.

20. Poggesi, Loredana et. al., Effect of Coenzyme Q10 on Left Ventricular Function in Patients with Dilative Cardiomyopathy. Current Therapeutic Research, 49(5): 878-886, 1991.

21. Ronca, G., Conte A. et. al., Synergic and Complementary Effects of L-Carnitine and Coenzyme Q on Long-Chain Fatty Acid Metabolism and on Protection against Anthracycline Damage. Int. J. Tiss. Reac., 12(3):197-201, 1990.

22. Scaglione, F. et. al., Coenzyme Q10 as an Immunoenhancer. A Single Blind Placebo-Controlled and Randomized Clinical Study. Conference of the International Coenzyme Q10 Association, Abstr. 89, 1998.