"All human studies included in the review were randomized controlled trials mainly conducted in high- to middle-income countries which highlighted that both oral and topical collagen supplements help to delay the aging process, with no differences arising between the two types of collagen. The evidence from the reviewed studies suggested that both collagen supplements improve skin moisture, elasticity, and hydration when orally administered. Additionally, collagen reduces the wrinkling and roughness of the skin, and existing studies have not found any side effects of its oral supplements."

Collagen Supplements for Aging and Wrinkles: A Paradigm Shift in the Fields of Dermatology and Cosmetics - Dermatol Pract Concept. 2022 Feb; 12(1): e2022018.

Collagen Peptides +

This unique formula is sourced from grass-fed, pasture-raised cows in Argentina and Brazil.   The cattle we select come from local farmers far from Buenos Aires who nurture only pasture-raised cattle.  Rigorous testing by outside laboratories is performed to ensure purity.  This formula is easy to use and is nearly flavorless and odorless.  Our cold liquid soluble formulation does not clump or congeal so you can enjoy the benefits of our formula in your favorite cold or warm beverage. Because it can be mixed into hot or cold, you can mix this formula in your favorite drinks, smoothies, cereals, oatmeal, or any other foods that you regularly enjoy.

This formula contains a unique protein peptide, glutamine, and fiber mixture.  These ingredients are crucial as we age and the body’s natural ability to produce connective tissue diminishes after the age of 25.   This low molecular weight protein peptide formula is easily digested and supports the body’s natural healing process.

These nutrients are also beneficial in strengthening the synovial membrane between the joints and in maintaining healthy cartilage weakened by overuse through impact and stress. Cartilage and joints are constantly being broken down and replaced. When a person does not have enough raw materials in their diet to combat the collagen breakdown, the joints begin to wear out. This formula is unique because of its large amounts of glycine and proline, which are found in lower amounts in other protein food supplements.

Continuous daily intake of this formula may benefit nails, hair, skin, ligaments, tendons and cartilage. ‡

Manufactured in a US FDA inspected facility.  GMP Compliant.   Purity and Potency Guaranteed!   We use the highest quality raw materials available. Testing is done at various stages of production.

Ingredients: 

Bovine Collagen Peptides: Beneficial in strengthening the synovial membrane between the joints and in maintaining healthy cartilage weakened by overuse through impact and stress. Cartilage and Joints are constantly being broken down and replaced. When a person does not have enough raw materials in their diet to combat the collagen breakdown, the joints begin to wear out. This formula is unique because of its large amounts of glycine and proline, which are found in lower amounts in other protein food supplements. 

Glutamine: A taste free amino acid that helps promote healthy muscles & healthy digestion. Glutamine may also help to curb appetite and decrease carbohydrate cravings.

Bamboo Fiber: Taste free, texture free, non thickening fiber. Most people do not get enough fiber in their diets so getting extra fiber where ever possible is a must. Fiber is important for proper bowel function, cholesterol elimination as well as healthy gut bacterial balance.

Benefits nails, hair, skin, ligaments, tendons and cartilage.

Visibly Young

This formula combines the most important vitamins, minerals, and concentrated phytonutrients for supporting healthy hair, skin, and nails.  Most diets today lack key nutrients that naturally support beauty through health.  If you have issues with weak and cracking nails, thinning skin or hair issues, this is the formula for you. ‡

Manufactured in a US FDA inspected facility.  GMP Compliant.   Purity and Potency Guaranteed!   We use the highest quality raw materials available. Testing is done at various stages of production. All IOH Nutrition Formulas Meet or Exceed cGMP Quality Standards.

Ingredients:

MSM: A form of elemental sulfur and a vital building block of joints, cartilage, skin, hair and nails. MSM supports many vital bio-chemical processes in the body, including energy production.

Camu Camu Fruit: A berry which contains powerful phytochemicals, beta carotene, calcium, iron, niacin, phosphorous, riboflavin and thiamin. It also contains naturally occurring vitamin C. 

Spirulina: A fresh-water blue-green algae, spriulina is an ideal anti-aging superfood, with concentrated nutrient value. It is easily digested, and loaded with antioxidants. This tiny aquatic plant offers 60% protein, B-complex vitamins, phytonutrients, rare essential fatty acids, and numerous minerals. It has been used for athletic nutrition, weight-loss, cardiovascular function and gastrointestinal health.

Cayenne: High in Vitamins A, C, B complex, calcium and potassium. Cayenne is a wonderful healing aid for all body systems, since it acts as a catalyst, increasing the effectiveness of other foods and herbs when used in conjunction with them. It is especially effective in healing digestive issues, rebuilding stomach tissue, and improving peristaltic action in the intestines. It also is believed to increase absorption of other nutrients taken with it.

Mineral Chelates: Minerals are all important for skin, hair and nail health. Chelation is a natural process that takes place in plants where the mineral is attached to an amino acids. Chelated minerals are much easier to absorb so it is important to take minerals as chelates to assure greater, more efficient mineral absorption. Mineral forms such as oxides and carbonates are not chelated.

Benefits:

• Have healthier skin, hair and nails.
• Enhance hair and nail growth.
• Strengthen the nails.
• Strengthen connective tissue. 

Liposomal Vitamin C

Our liposomes have a uniform lipid structure and therefore are more effective.  We utilize a unique cold-water construction process to ensure the highest quality, purest and best absorbed product available. No alcohol or heat is used in production.  Soy-free, gluten-free, non-GMO, non-hydrogenated, non-hydroxylated phosphatidylcholine, true liposome technology. 

Vitamin C is a critical co-factor to Collagen synthesis along with Vitamin E. ‡

Manufactured in a US FDA inspected facility.  GMP Compliant.   Purity and Potency Guaranteed!   We use the highest quality raw materials available. Testing is done at various stages of production.

‡ These statements have not been evaluated by the FDA. These products are not intended to diagnose, treat, cure or prevent any disease.

References

1. Liu, J., Wang, Y., Song, S., Wang, X., Qin, Y., Si, S., &Guo, Y. (2015). Combined oral administration of bovine collagen peptides with calcium citrate inhibits bone loss in ovariectomized rats. PloS one, 10(8), e0135019. doi:10.1371/ journal.pone.0135019

2. Avila Rodríguez, MI, Rodríguez Barroso, LG, Sánchez, ML. Collagen: A review on its sources and potential cosmetic applications. J CosmetDermatol. 2018; 17: 20– 26. https://doi.org/10.1111/jocd.12450

3. Vollmer, D. L., West, V. A., &Lephart, E. D. (2018). Enhancing Skin Health: By Oral Administration of Natural Com- pounds and Minerals with Implications to the Dermal Microbiome. International journal of molecular sciences, 19 (10), 3059. doi:10.3390/ijms19103059

4. Varani, J., Dame, M. K., Rittie, L., Fligiel, S. E., Kang, S., Fisher, G. J., & Voorhees, J. J. (2006). Decreased collagen pro- duction in chronologically aged skin: roles of age-dependent alteration in fibroblast function and defective mechani- cal stimulation. The American journal of pathology, 168(6), 1861–1868. doi:10.2353/ajpath.2006.051302

5. Hakuta, A., Yamaguchi, Y., Okawa, T., Yamamoto, S., Sakai, Y., &Aihara, M. (2017). Anti-inflammatory effect of colla- gen tripeptide in atopic dermatitis. Journal of dermatological science, 88(3), 357-364.

6. Matsuda, N., Koyama, Y. I., Hosaka, Y., Ueda, H., Watanabe, T., Araya, T., ...&Takehana, K. (2006). Effects of ingestion of collagen peptide on collagen fibrils and glycosaminoglycans in the dermis. Journal of nutritional science and vita- minology, 52(3), 211-215.

7. Tanaka, M., Koyama, Y. I., & Nomura, Y. (2009). Effects of collagen peptide ingestion on UV-B-induced skin dam- age. Bioscience, biotechnology, and biochemistry, 73(4), 930-932.

8. Liu, J., Zhang, B., Song, S., Ma, M., Si, S., Wang, Y., ...Guo, Y. (2014). Bovine collagen peptides compounds promote the proliferation and differentiation of MC3T3-E1 pre-osteoblasts. PloS one, 9(6), e99920. doi:10.1371/ journal.pone.0099920

9. Rao, R., &Samak, G. (2012). Role of Glutamine in Protection of Intestinal Epithelial Tight Junctions. Journal of epithe- lial biology & pharmacology, 5(Suppl 1-M7), 47–54. doi:10.2174/1875044301205010047

10. Pithon-Curi, T. C., Schumacher, R. I., Freitas, J. J., Lagranha, C., Newsholme, P., Palanch, A. C., ... &Curi, R. (2003). Glutamine delays spontaneous apoptosis in neutrophils. American Journal of Physiology-Cell Physiology, 284(6), C1355-C1361.

11. Miller, A. L. (1999). Therapeutic considerations of L-glutamine: a review of the literature. Alternative medicine re- view: a journal of clinical therapeutic, 4(4), 239-248.

12. Philip Newsholme, Why Is L-Glutamine Metabolism Important to Cells of the Immune System in Health, Postinjury, Surgery or Infection?, The Journal of Nutrition, Volume 131, Issue 9, September 2001, Pages 2515S–2522S, https:// doi.org/10.1093/jn/131.9.2515S

13. Shi, Q. T., & Yang, K. S. (1992, December). Study on relationship between nutrients in bamboo shoots and human health. In Proceedings of the International Symposium on Industrial Use of Bamboo. International Tropical Timber Or- ganization and Chinese Academy, Beijing, China: Bamboo and its Use (pp. 338-346).

14. Chongtham, N., Bisht, M.S. and Haorongbam, S. (2011), Nutritional Properties of Bamboo Shoots: Potential and Pros- pects for Utilization as a Health Food. Comprehensive Reviews in Food Science and Food Safety, 10: 153-168. doi:10.1111/j.1541-4337.2011.00147.x

15. Hu, C., Zhang, Y., & Kitts, D. D. (2000). Evaluation of antioxidant and prooxidant activities of bamboo Phyllostachys- nigra var. Henonis leaf extract in vitro. Journal of Agricultural and Food Chemistry, 48(8), 3170-3176.

16. Kaczmarczyk, M. M., Miller, M. J., & Freund, G. G. (2012). The health benefits of dietary fiber: beyond the usual sus- pects of type 2 diabetes mellitus, cardiovascular disease and colon cancer. Metabolism, 61(8), 1058-1066.

References

1. Patel, D. P., Swink, S. M., & Castelo-Soccio, L. (2017). A Review of the Use of Biotin for Hair Loss. Skin appendage disorders, 3(3), 166–169. doi:10.1159/000462981

2. Schwalfenberg, G. K., &Genuis, S. J. (2017). The Importance of Magnesium in Clinical Healthcare. Scientifica, 2017, 4179326. doi:10.1155/2017/4179326

3. Michaëlsson G, Juhlin L, Vahlquist A. Effects of Oral Zinc and Vitamin A in Acne. Arch Dermatol. 1977;113(1):31–36. doi:10.1001/archderm.1977.01640010033003

4. Tinggi U. (2008). Selenium: its role as antioxidant in human health. Environmental health and preventive medicine, 13(2), 102–108. doi:10.1007/s12199-007-0019-4

5. Borkow G. (2014). Using Copper to Improve the Well-Being of the Skin. Current chemical biology, 8(2), 89–102. doi:10.2174/2212796809666150227223857

6. Park K. (2015). Role of micronutrients in skin health and function. Biomolecules & therapeutics, 23(3), 207–217. doi:10.4062/biomolther.2015.003

7. Ryan-Harshman, M., &Aldoori, W. (2005). Health benefits of selected minerals. Canadian family physician, 51(5), 673.

8. Nielsen, FH . Evidence for the nutritional essentiality of boron. J Trace Elem Exp Med. 1996;9:215–229.

9. Nielsen, F. H., & Meacham, S. L. (2011). Growing Evidence for Human Health Benefits of Boron. Journal of EvidenceBased Complementary & Alternative Medicine, 16(3), 169–180. https://doi.org/10.1177/2156587211407638

10. Nielsen, F. H. (1999). THE BALDERDASH AND REALITIES OF HEALTH AND PERFORMANCE CLAIMS FOR SUPPLEMENTS AS EXEMPLIFIED BY CALCIUM CHROMIUM AND VANADIUM. Proceedings of the North Dakota Academy of Science, 53.

11. Crane, M. (2015). Ingestible MSM Ingredient May Reduce Wrinkles, Improve Skin Texture.

12. Delsin, S. D., Mercurio, D. G., Fossa, M. M., & Maia Campos, P. M. B. G. (2015). Clinical efficacy of dermocosmetic formulations containing Spirulina extract on young and mature skin: effects on the skin hydrolipidic barrier and structural properties. ClinPharmacolBiopharm, 4(144), 2.

13. Costa, J. A. V., Barbieri Moro, G. M., de MoraesVaz Batista Filgueira, D., Corsini, E., &Bertolin, T. E. (2017). The Potential of Spirulina and Its Bioactive Metabolites as Ingested Agents for Skin Care. Industrial Biotechnology, 13(5), 244- 252.

14. Langley, P. C., Pergolizzi Jr, J. V., Taylor Jr, R., & Ridgway, C. (2015). Antioxidant and associated capacities of Camucamu (Myrciariadubia): a systematic review. The journal of alternative and complementary medicine, 21(1), 8-14.

15. Gründemann, C., Lengen, K., Sauer, B., Garcia-Käufer, M., Zehl, M., & Huber, R. (2014). Equisetum arvense (common horsetail) modulates the function of inflammatory immunocompetent cells. BMC complementary and alternative medicine, 14, 283. doi:10.1186/1472-6882-14-283