DIM+ Estrogen Metabolism & Detox Support.
DIM+ / Estrogen Metabolism & Liver Detoxification Support
Your body doesn't just make hormones. It has to clear them.
DIM+ is built around the second half of that job — the part almost nobody supports. Nine actives, every one disclosed at its exact milligram amount, aimed at how estrogen is metabolized in the liver and escorted out of the body rather than recycled back in.
100 mgDIM per serving
400 mgCalcium D-Glucarate
9Actives, fully disclosed
30-DaySupply at 2 capsules
Why we formulated this one
Most men chase the production number. The clearance side is where the story usually is.
Men spend a lot of money trying to make more testosterone. Far fewer pay attention to what happens on the other end of the pathway — how estrogen gets metabolized, conjugated, and eliminated.
Estrogen metabolism is a multi-step process. In the first phase, the liver hydroxylates estrogen into different metabolite families. In the second phase, those metabolites get tagged for exit through methylation, sulfation, and glucuronidation. Then they leave through bile and the gut. If any of those steps is running poorly, the metabolites don't disappear. Some of them get deconjugated by bacterial enzymes in the gut and reabsorbed back into circulation.
That is the mechanism DIM+ was built around. We did not build a testosterone booster. We built a clearance and metabolism formula for men who want to support the pathway that decides where their estrogen actually goes.
We formulated DIM+ because I wanted a single capsule that addressed both phases of estrogen metabolism and the gut reabsorption step, without stacking three separate bottles to do it.
The difference
What a typical DIM product does, and what we did instead.
Industry standard
A single ingredient in a capsule
- DIM alone, with nothing supporting the conjugation step that follows it
- Doses buried inside a "hormone blend" with no individual amounts printed
- Marketing built on the words estrogen blocker, which is drug language, not supplement science
- No mention of gut reabsorption, which is where a meaningful part of the load comes back
- Standardization percentages left off the label, so you cannot calculate what you are actually getting
The IOH standard
The whole pathway, priced honestly
- DIM at 100 mg, paired with calcium D-glucarate, sulforaphane, and lignans across the same pathway
- Every active printed at its exact milligram amount. No proprietary blend
- Standardization percentages disclosed so you can do the math on active yield yourself
- A published dose ledger on this page showing where our amounts sit relative to research ranges, including where they sit low
- Support language only. We describe mechanisms. We do not claim to block, treat, or replace anything
What DIM+ supports
Four jobs, one capsule.
01
Healthy Estrogen Metabolism
DIM supports the liver's phase I handling of estrogen and the balance among the metabolite families it produces.
02
Phase II Conjugation
Sulforaphane and silymarin support the glutathione system and the phase II enzymes that tag metabolites for exit.
03
Elimination, Not Recycling
Calcium D-glucarate and flax lignans support the gut side of the pathway, where conjugated metabolites are meant to leave.
04
Antioxidant Defense
Green tea polyphenols and vitamin E support cellular antioxidant status in tissues that are metabolically busy.
The signature idea
The estrogen exit route, and where each ingredient sits on it.
Estrogen leaves the body along a route with four distinct stops. Support one stop and ignore the rest and you have a bottleneck. This is the map we formulated against, stop by stop.
Stop 01
Phase I — Hydroxylation
In the liver, estrogen is hydroxylated into several metabolite families. The proportions among them are influenced by diet, body composition, and cruciferous intake.
DIM · Broccoli sprout concentrate
Stop 02
Phase II — Conjugation
Those metabolites are then tagged for removal through methylation, sulfation, and glucuronidation. This is glutathione-dependent enzymatic work.
Sulforaphane · Silymarin · Green tea catechins
Stop 03
Bile and Gut Transit
Conjugated metabolites move into bile and down into the intestine. From here, they are either bound and carried out, or they are acted on by gut bacterial enzymes.
Flaxseed lignans · Dietary fiber intake
Stop 04
Exit, Not Reabsorption
Bacterial beta-glucuronidase can cleave the glucuronide tag and free the metabolite for reabsorption. Calcium D-glucarate is the ingredient in this formula aimed squarely at that step.
Calcium D-glucarate
Straight talk on this diagram
This is a description of a well-characterized metabolic pathway and where each ingredient has been studied to act. It is not a claim that DIM+ moves any specific lab value in any specific person. Individual estrogen metabolism is influenced by body fat, alcohol intake, fiber, sleep, medications, and genetics, and no capsule overrides those inputs.
Inside the formula
Nine actives. Every amount printed.
Amounts below are per two-capsule serving. Where an ingredient is standardized, we have printed the percentage so you can calculate the actual active yield instead of taking a raw milligram number at face value.
Diindolylmethane (DIM)
100 mg
The anchor ingredient · Cruciferous-derived
DIM is what your body forms from indole-3-carbinol after you eat broccoli, cabbage, kale, or Brussels sprouts. It is the compound that has been studied for its influence on how the liver hydroxylates estrogen in phase I, and on the resulting balance among estrogen metabolite families.
This is the ingredient the product is named for, and it is dosed in the range used in published human work on estrogen metabolite ratios. That is deliberate. We did not want the headline ingredient to be the one hiding at a fairy-dust amount while the label leans on it.
Straight talk
DIM's absorption varies widely depending on formulation. Crystalline DIM absorbs poorly on its own; bioavailability-enhanced forms behave differently. We are confirming which form this batch uses and will state it here rather than imply a delivery advantage we have not verified.
Calcium D-Glucarate
400 mg
Supplies 40 mg elemental calcium · 3% Daily Value
Glucuronidation is one of the liver's main exit tags. The liver attaches glucuronic acid to a compound, which makes it water-soluble and ready to leave through bile. The catch is that bacterial beta-glucuronidase in the gut can cut that tag off, which frees the compound for reabsorption back into circulation.
Calcium D-glucarate converts in the gut to D-glucaro-1,4-lactone, which is the form studied for its inhibition of that bacterial enzyme. This is the ingredient that addresses the recycling step, and it is the reason this formula is not just a DIM capsule.
Straight talk on this dose
400 mg sits below the amounts most commonly used in the human and animal glucuronidation literature, which have generally run in the range of 500 mg taken multiple times daily. We are telling you that rather than letting the 400 mg number stand next to research it does not match. See the dose ledger below.
Flaxseed Lignan Concentrate
100 mg
Standardized to 20% SDG · Yields approximately 20 mg secoisolariciresinol diglucoside
Flax lignans are converted by gut bacteria into enterolignans, which are structurally similar to endogenous estrogens and interact with the same receptors weakly. That weak interaction, plus their behavior in the gut, is why lignans show up in the estrogen metabolism literature and in cardiovascular and prostate health research.
In this formula, the lignan concentrate sits at the gut transit stop on the exit route, alongside calcium D-glucarate.
Straight talk on this dose
At 20% SDG, 100 mg of concentrate yields roughly 20 mg of actual SDG. Human lignan studies have typically used more. This is a contributing dose within a multi-ingredient pathway formula, not a standalone lignan dose, and we are not going to present it as one.
Chrysin
100 mg
Flavonoid · Traditionally sourced from passionflower and propolis
Chrysin is a naturally occurring flavone. In laboratory settings it has been studied for its interaction with aromatase, the enzyme that converts androgens to estrogens, and it carries antioxidant activity in cell models.
Straight talk, and this one matters
We are not going to sell you chrysin as an estrogen blocker, because the human evidence does not support that framing. Oral chrysin is extensively conjugated in the intestinal wall before it reaches circulation, and its measured oral bioavailability is very low. A controlled human study using several grams per day for three weeks found no meaningful change in testosterone or estradiol. Chrysin is present in this formula as a flavonoid with antioxidant activity. If you are buying DIM+ specifically for chrysin, buy something else.
Broccoli Sprout Concentrate
50 mg
Standardized to 5% sulforaphane · Yields approximately 2.5 mg sulforaphane
Sulforaphane is the most studied Nrf2 activator in the food supply. Nrf2 is a transcription factor that upregulates a family of phase II detoxification enzymes, including those involved in glutathione synthesis. It is the ingredient in this formula most directly tied to the conjugation stop on the exit route.
Straight talk on this dose
Five percent of 50 mg is 2.5 mg of sulforaphane. Clinical work on Nrf2 activation and phase II enzyme induction has generally used considerably more. This is a supportive inclusion, not a clinical sulforaphane dose, and we would rather say that on the page than let a reader assume otherwise from the ingredient name.
Milk Thistle Extract
50 mg
Seed · Standardized to 80% silymarin · Yields approximately 40 mg silymarin
Silymarin is a flavonolignan complex from milk thistle seed with a long history of use in support of normal liver function and hepatic antioxidant status. Since every step upstream of the gut on this exit route happens in the liver, liver support belongs in an estrogen metabolism formula.
Straight talk on this dose
Silymarin research has commonly used doses well above 40 mg per day, often several hundred milligrams divided across the day. At this amount, milk thistle is a supporting component of a pathway formula. If liver support is your primary goal, a dedicated silymarin product is the more honest tool.
Green Tea Extract, Decaffeinated
50 mg
Leaf · 95% polyphenols, 75% catechins · Yields approximately 37 mg catechins
Green tea catechins are among the best-characterized dietary polyphenols for antioxidant support and cellular defense. We specified the decaffeinated extract on purpose. This is a formula men take daily, often alongside coffee, a pre-workout, or both, and there was no reason to add stimulant load to a detoxification support product.
Straight talk on this dose
Green tea studies on metabolic outcomes typically use catechin amounts many times higher than 37 mg. Here, green tea is an antioxidant contributor to the formula matrix. We are not attaching any metabolic or fat oxidation percentage from a higher-dose study to this amount.
Vitamin E, from Sunflower
5 mg
33% Daily Value · Natural source, not synthetic dl-alpha
Vitamin E is the primary fat-soluble antioxidant in cell membranes. We specified sunflower-derived natural vitamin E rather than the synthetic dl-alpha form, because the natural form is retained in tissue more effectively at equivalent amounts. At 5 mg, it functions here as formula-level antioxidant support and as protection for the lipid-soluble components in the capsule.
The dose ledger
We publish this on every page where a dose sits below the range used in the research. You should be able to see what you are buying without decoding a label.
| Ingredient | In DIM+ per serving | Where research has generally run | Our read |
|---|---|---|---|
| DIM | 100 mg | Human estrogen-metabolite work has commonly used 100 to 200 mg daily | In range at the lower end |
| Calcium D-glucarate | 400 mg | Commonly 500 mg, often taken more than once daily | Below typical study intake |
| Flax lignans (SDG) | ~20 mg SDG | Lignan trials have generally used higher SDG amounts | Contributing dose |
| Sulforaphane | ~2.5 mg | Nrf2 and phase II work has used substantially more | Supportive, not clinical |
| Silymarin | ~40 mg | Liver studies commonly use several hundred mg daily | Supportive, not clinical |
| Green tea catechins | ~37 mg | Metabolic studies use many times this amount | Antioxidant contributor |
| Chrysin | 100 mg | Oral bioavailability is very low regardless of dose | Included as a flavonoid; no hormonal claim made |
Why we publish this
Because you can verify it, and because a formula that is honest about its supporting ingredients is easier to trust on its anchor ingredients. DIM+ is a DIM and calcium D-glucarate formula with a botanical support matrix around it. That is what it is, and that is how we sell it.
Supplement Facts
| Amount Per Serving | % Daily Value | |
|---|---|---|
| Vitamin E (from sunflower) | 5 mg | 33% |
| Calcium (from Calcium D-Glucarate) | 40 mg | 3% |
| Calcium D-Glucarate | 400 mg | † |
| Diindolylmethane (DIM) | 100 mg | † |
| Chrysin | 100 mg | † |
| Flaxseed Lignan Concentrate (20% SDG) | 100 mg | † |
| Milk Thistle Extract (seed) (80% silymarin) | 50 mg | † |
| Broccoli Sprout Concentrate (5% sulforaphane) | 50 mg | † |
| Green Tea Extract (leaf) (95% polyphenols, 75% catechins, decaffeinated) | 50 mg | † |
† Daily Value not established.
Other Ingredients: Vegetarian capsule (hypromellose), and standard flow agents as listed on the printed label.
60 Vegetarian Capsules
The printed Supplement Facts panel is also shown in the product images. If anything differs between this table and the physical label, the physical label governs.
The short version
DIM+ at a glance.
What it is
A nine-active vegetarian capsule built around diindolylmethane and calcium D-glucarate, with a supporting matrix of sulforaphane, silymarin, flax lignans, green tea catechins, chrysin, and vitamin E. Sixty capsules. Thirty servings.
What it does
Supports healthy estrogen metabolism, normal phase II liver detoxification pathways, healthy glucuronidation, and antioxidant defense. It is a metabolism and clearance formula, not a hormone replacement or a testosterone booster.
Who it's for
- Men who want to support the clearance side of hormone metabolism, not just the production side
- Men carrying more body fat than they want, since adipose tissue is metabolically active
- Anyone already eating cruciferous vegetables who wants consistent daily intake
- Men working with a physician on lab-based protocols
How to take it
Two vegetarian capsules daily, with food. Taking DIM with a meal that contains some fat improves absorption. If you are on prescription medication, or you have a hormone-sensitive condition, talk to your physician before starting. See the medication FAQ below.
Honest expectations
The first ninety days, without the hype.
Nobody can tell you how you will feel on a given day or promise you a timeline. What we can tell you is how this category of ingredient behaves and what a reasonable person should watch for.
Days 1 – 14
Consistency and tolerance
Take it daily with food. Most men notice nothing dramatic in this window, and that is normal. Some people notice their urine takes on an amber or orange tint. That is a known and harmless characteristic of DIM, not a warning sign.
Days 15 – 45
The pathway does its work quietly
Estrogen metabolism is not something you feel happening. This is the stretch where the daily habit matters more than any sensation. If you are tracking anything, track your training, your sleep, and your waistline, not how you feel an hour after the capsule.
Days 46 – 90
Look at data, not feelings
This is a formula that should be judged by lab work, not by sensation. If you are going to evaluate it properly, get a baseline before you start and recheck after roughly ninety days with your physician. That is how I use it, and it is how I would want you to use it.
What to look for
How to read any estrogen metabolism product, including this one.
These are the questions we think you should ask before buying anything in this category. We have answered them for DIM+ so you can hold the next label to the same standard.
| The question | Typical off-the-shelf DIM | DIM+ |
|---|---|---|
| Is every active dose printed? | Frequently folded into a proprietary hormone blend with a single total weight | Yes. All nine actives printed at their exact milligram amount |
| Are standardization percentages disclosed? | Often omitted, so active yield cannot be calculated | Yes. 20% SDG, 5% sulforaphane, 80% silymarin, 95% polyphenols, 75% catechins |
| Does the formula address gut reabsorption? | Usually not. Most are DIM only | Yes. Calcium D-glucarate at 400 mg targets the glucuronidation recycling step |
| Does it cover both phases of liver metabolism? | Phase I only, if that | Phase I and phase II ingredients are both present and identified by stop on the pathway |
| Does the seller disclose where doses fall short? | Almost never | Yes. Published dose ledger on this page, including the ingredients we dose low |
| Is the marketing language defensible? | Estrogen blocker, aromatase inhibitor, and testosterone booster language is common | Structure and function language only. No blocker, inhibitor, or drug-substitute framing |
| Is stimulant load avoided? | Green tea is often included with caffeine intact | Decaffeinated green tea extract specified deliberately |
| Vegetarian capsule? | Frequently bovine gelatin | Vegetarian capsule |
Proof, not promises
What we will put in writing.
Everything on this list is either printed on the label, verifiable from the panel, or a statement about how we built the page. Nothing on this list is a promise about how you will feel.
- Nine actives, each printed at its exact milligram amount. No proprietary blend anywhere on this label
- Standardization percentages disclosed for every standardized extract in the formula
- A published dose ledger that names the ingredients dosed below research ranges instead of hiding them
- Chrysin described accurately, including its bioavailability limitation, rather than sold as an estrogen blocker
- Decaffeinated green tea extract, so this stacks cleanly with coffee or a pre-workout
- Vegetarian capsule
- Manufactured in a United States FDA-registered facility operating under current Good Manufacturing Practices
- Support language throughout. No disease claims, no drug comparisons, no promised timelines
Manufacturing and standardization
How this product is made.
We only publish what is documented for this specific product. If a claim is not documented for DIM+, it does not appear on this page, even if it is true of another product in the line.
FDA-Registered Facility
DIM+ is manufactured in a United States facility that is registered with the FDA. Registration is a filing requirement, not an FDA endorsement or approval of the product, and we will not describe it as one.
cGMP Compliant
Production follows current Good Manufacturing Practice requirements, which govern identity, purity, strength, and composition controls across the manufacturing process.
Standardized Raw Materials
Every botanical extract in this formula is standardized to a stated marker compound percentage, printed on the label and on this page, so that active yield is calculable rather than assumed.
Dr. Andreas Boettcher, B.S., D.C., C.F.M.P.
Founder, It's Only Halftime
Ironman Triathlete / Master's Men's Physique Competitor / Medication-Free at 56 / 33 Years of Clinical Practice
In thirty-three years of practice, the men who got the best results were rarely the ones chasing a single number. They were the ones who understood that a hormone you cannot clear is a hormone that keeps working on you.
I take this one myself. I train hard, I compete, and I am medication-free at fifty-six, and that is not because of any single capsule. It is because I pay attention to the whole pathway. DIM+ is the piece of that I did not want to have to assemble from three separate bottles.
Get baseline labs. Take it consistently. Recheck with your physician. That is how I would want my own patients to use it.
Build the stack
What DIM+ pairs with in the IOH line.
DIM+ handles metabolism and clearance. These are the products that sit on either side of it.
Amplify T
The production side
DIM+ works on the clearance end of the pathway. Amplify T works on the other end. Together they cover both halves of the conversation instead of one.
Detox Binder
The exit step
Once metabolites are conjugated and moved into the gut, binding capacity matters. Detox Binder supports the final carry-out step at the end of the same route.
GI Clear Elite
The gut terrain
Bacterial beta-glucuronidase activity is a function of gut ecology. Supporting a healthier gut environment supports the same reabsorption step calcium D-glucarate is aimed at.
FAQ
Questions, answered.
Is DIM+ a testosterone booster?
No, and we are not going to market it as one. DIM+ is an estrogen metabolism and liver detoxification support formula. It works on how hormones are metabolized and eliminated, not on stimulating production. If production support is what you are after, that is a different product and a different conversation with your physician.
My urine turned orange. Is something wrong?
No. An amber or orange tint to urine is a well-known and harmless characteristic of DIM supplementation. It is a pigment effect, it is temporary, and it resolves when you stop. It is probably the single most common question we get on this product.
Medications and safety — what should I know before starting?
This formula has real interaction potential and you should read this section rather than skip it. Talk to your physician or pharmacist before starting if any of the following apply to you.
DIM can influence CYP1A2 enzyme activity, which is relevant to medications metabolized through that route, including certain antipsychotics such as clozapine, and theophylline. Calcium D-glucarate supports glucuronidation, which is the clearance route for a number of drugs, including acetaminophen, certain statins, oral contraceptives, lamotrigine, valproate, and some opioids. Supporting that pathway can in principle lower circulating levels of drugs that depend on it.
Milk thistle has documented interaction potential through CYP2C9 and glucuronidation enzymes, which is relevant to warfarin and some diabetes medications. Green tea catechins can reduce absorption of certain beta blockers, notably nadolol. Flax lignans have weak estrogen receptor activity, which is a consideration for anyone on hormone therapy, tamoxifen, aromatase inhibitors, or with a hormone-sensitive condition.
Do not use this product if you are pregnant, may become pregnant, or are nursing. This product is formulated for adult men. If you have a diagnosed liver, kidney, or hormone-related condition, do not start without physician supervision.
Why is chrysin in the formula if you say the evidence is weak?
Because it is a flavonoid with antioxidant activity, and it is in the formula as built. What we will not do is put "natural estrogen blocker" on the page next to it. Oral chrysin is heavily conjugated in the intestinal wall before it reaches circulation, and a controlled human study at multi-gram daily doses over three weeks did not move testosterone or estradiol. We would rather tell you that up front than have you find it later and wonder what else we shaded.
Should I take it with food?
Yes. DIM and vitamin E are fat-soluble, and absorption improves when they are taken with a meal that contains some fat. Two capsules once daily with a meal is the simplest way to stay consistent, and consistency matters more here than timing.
Can women take DIM+?
DIM and calcium D-glucarate are both used in women's protocols clinically. That said, this particular formula was written for men, the marketing on this page speaks to men, and hormone-sensitive conditions are more common on the women's side. If you are a woman considering it, have that conversation with your physician first rather than treating this page as guidance for you.
How long should I stay on it before deciding whether it works?
We are not going to give you a promised timeline, because nobody honestly can. What I will tell you is how to evaluate it properly: get baseline labs before you start, take it consistently every day, and recheck with your physician after roughly ninety days. This is a formula to judge by data, not by sensation.
Is there caffeine in it?
No. We specified a decaffeinated green tea extract deliberately, so DIM+ stacks cleanly alongside coffee, a pre-workout, or an evening routine without adding stimulant load.
Are there proprietary blends in this formula?
None. Every active is printed individually with its exact milligram amount and, where applicable, its standardization percentage. You can calculate active yield on every extract in this bottle without calling us.
DIM+ / Estrogen Metabolism & Liver Detox Support
Half the pathway is production. This is the other half.
You can spend years and a lot of money trying to move one number up, while the pathway that decides what happens to your hormones downstream goes completely unaddressed. Most men in this category are doing exactly that, because that is what the category sells them.
DIM+ is the other half of the conversation. One hundred milligrams of DIM, four hundred milligrams of calcium D-glucarate, and a supporting matrix across phase I, phase II, and the gut reabsorption step. Nine actives, every amount printed, standardization percentages disclosed, and a dose ledger on this page that tells you exactly where our numbers sit against the research — including where they sit low, because you deserve to know that before you buy, not after.
We built the formula I wanted to take every day. Two capsules, with food, consistently. Then check your labs and let the data tell you the truth.
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