{"product_id":"tmg-tri-methyl-complex-for-powerful-methylation-support","title":"TMG Tri-Methyl Complex for Powerful Methylation Support","description":"\u003c!-- ============================================================\n IOH NUTRITION — TMG Tri-Methyl Complex\n Shopify Product Description block. Paste into the Description field only.\n No hero, no buy box, no price, no Add to Cart. Those already exist above.\n All CSS scoped under .ioh-desc\n ------------------------------------------------------------\n OPEN ITEMS BEFORE PUBLISH (see handoff notes):\n 1. Bottle art reads \"TMG Methyl Complex\". This page reads \"TMG Tri-Methyl Complex\".\n Resolve before print or before storefront title is set.\n 2. Biotin: printed label reads \"50 mg\". Panel below reads 50 mcg, which is what\n 166% DV actually equals. Label reprint required.\n 3. Product image: replace the commented \u003cimg\u003e tag in the PROOF section with the\n hosted Shopify Files CDN URL once the bottle shot is uploaded.\n 4. Stack cards carry no links yet. 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font-size:13px;line-height:1.45;padding:5px 0;border-bottom:1px solid var(--black);\n vertical-align:top;\n}\n.ioh-desc .ioh-panel td .src{font-size:11.5px;color:#333;display:block;line-height:1.4;}\n.ioh-desc .ioh-panel td.amt,.ioh-desc .ioh-panel td.dv{white-space:nowrap;font-size:13px;padding-left:8px;}\n.ioh-desc .ioh-panel .thick td{border-top:5px solid var(--black);}\n.ioh-desc .ioh-panel .nodv{border-bottom:0;}\n.ioh-desc .ioh-panel .pfoot{font-size:12px;line-height:1.5;margin:8px 0 0;}\n.ioh-desc .ioh-panel .oi{\n font-size:12px;line-height:1.5;margin:10px 0 0;border-top:5px solid var(--black);padding-top:8px;\n}\n.ioh-desc .ioh-panel-cap{\n font-family:var(--mono);font-size:12px;letter-spacing:.06em;color:var(--muted);\n text-align:center;margin:16px auto 0;max-width:520px;line-height:1.6;\n}\n\n\/* ---------- 8. quad ---------- *\/\n.ioh-desc .ioh-quad{display:grid;grid-template-columns:repeat(4,1fr);gap:0;margin-top:30px;\n border:1px solid var(--silver-light);border-radius:14px;overflow:hidden;}\n.ioh-desc .ioh-qcell{padding:26px 22px;border-right:1px solid var(--silver-light);}\n.ioh-desc .ioh-qcell:last-child{border-right:0;}\n.ioh-desc .ioh-qcell .qh{\n font-family:var(--mono);font-size:13px;font-weight:700;letter-spacing:.1em;\n text-transform:uppercase;color:var(--blue);display:block;margin-bottom:12px;\n}\n.ioh-desc .ioh-qcell p{font-size:16.5px;margin:0 0 10px;}\n.ioh-desc .ioh-qcell p:last-child{margin-bottom:0;}\n.ioh-desc .ioh-qcell ul{margin:0;padding-left:18px;}\n.ioh-desc .ioh-qcell li{font-size:16.5px;line-height:1.55;margin-bottom:7px;}\n\n\/* ---------- 9. timeline ---------- *\/\n.ioh-desc .ioh-tl{display:grid;grid-template-columns:repeat(3,1fr);gap:20px;margin-top:32px;}\n.ioh-desc .ioh-tlcard{\n background:var(--silver-pale);border:1px solid var(--silver-light);border-radius:14px;\n padding:26px 22px;border-top:4px solid var(--blue);\n}\n.ioh-desc .ioh-tlcard .w{\n font-family:var(--mono);font-size:13px;font-weight:600;letter-spacing:.11em;\n text-transform:uppercase;color:var(--blue-dark);display:block;margin-bottom:11px;\n}\n.ioh-desc .ioh-tlcard p{font-size:16.5px;margin:0;}\n\n\/* ---------- 10. comparison ---------- *\/\n.ioh-desc .ioh-cmp-scroll{overflow-x:auto;margin-top:30px;-webkit-overflow-scrolling:touch;}\n.ioh-desc .ioh-cmp{width:100%;border-collapse:collapse;min-width:640px;}\n.ioh-desc .ioh-cmp th{\n font-family:var(--mono);font-size:12.5px;font-weight:600;letter-spacing:.08em;\n text-transform:uppercase;padding:13px 14px;text-align:left;\n}\n.ioh-desc .ioh-cmp thead th{background:var(--ink);color:var(--white);}\n.ioh-desc .ioh-cmp thead th.hl{background:var(--blue);}\n.ioh-desc .ioh-cmp tbody th{\n background:var(--silver-pale);color:var(--ink);border-bottom:1px solid var(--silver-light);\n font-family:var(--sans);font-size:16.5px;font-weight:700;letter-spacing:0;text-transform:none;\n width:24%;\n}\n.ioh-desc .ioh-cmp td{\n font-size:16.5px;padding:13px 14px;border-bottom:1px solid var(--silver-light);\n vertical-align:top;\n}\n.ioh-desc .ioh-cmp td.ours{background:var(--blue-light);color:var(--ink);font-weight:600;}\n\n\/* ---------- 11. proof ---------- *\/\n.ioh-desc .ioh-proof{display:grid;grid-template-columns:1.15fr .85fr;gap:34px;align-items:start;margin-top:26px;}\n.ioh-desc .ioh-checks{margin:0;padding:0;list-style:none;}\n.ioh-desc .ioh-checks li{\n font-size:17.5px;line-height:1.55;padding:13px 0 13px 34px;position:relative;\n border-bottom:1px solid var(--silver-light);\n}\n.ioh-desc .ioh-checks li::before{\n content:\"✓\";position:absolute;left:0;top:12px;color:var(--white);background:var(--blue);\n width:21px;height:21px;border-radius:50%;font-size:12px;line-height:21px;text-align:center;font-weight:700;\n}\n.ioh-desc .ioh-shot{\n background:var(--silver-pale);border:1px solid var(--silver-light);border-radius:14px;\n padding:22px;text-align:center;\n}\n.ioh-desc .ioh-shot img{border:1px solid var(--silver-light);border-radius:10px;background:var(--white);}\n.ioh-desc .ioh-shot .cap{\n font-family:var(--mono);font-size:12.5px;letter-spacing:.06em;color:var(--muted);\n margin-top:14px;line-height:1.6;\n}\n\n\/* ---------- 12. quality card ---------- *\/\n.ioh-desc .ioh-qual{\n background:var(--blue-light);border:1px solid rgba(0,118,182,.28);border-radius:14px;\n padding:34px 30px;margin-top:26px;\n}\n.ioh-desc .ioh-qgrid{display:grid;grid-template-columns:repeat(3,1fr);gap:22px;margin-top:24px;}\n.ioh-desc .ioh-qitem .qt{\n font-family:var(--mono);font-size:12.5px;font-weight:600;letter-spacing:.1em;\n text-transform:uppercase;color:var(--blue-dark);display:block;margin-bottom:8px;\n}\n.ioh-desc .ioh-qitem p{font-size:16.5px;margin:0;}\n\n\/* ---------- 13. physician band ---------- *\/\n.ioh-desc .ioh-band{background:var(--black);padding:60px 26px;}\n.ioh-desc .ioh-band .ioh-narrow{max-width:820px;}\n.ioh-desc .ioh-band p{color:#C7D0D6;font-size:18px;}\n.ioh-desc .ioh-band .pq{\n font-family:var(--serif);font-size:clamp(20px,2.3vw,25px);line-height:1.5;color:var(--white);\n margin:0 0 20px;\n}\n.ioh-desc .ioh-photo{\n width:100%;max-width:300px;border-radius:14px;margin:0 auto 20px;display:block;\n border:1px solid #232B31;\n}\n.ioh-desc .ioh-photo-cap{\n font-family:var(--mono);font-size:12.5px;letter-spacing:.07em;text-indent:.07em;\n color:#7C878E;text-align:center;margin:0 0 30px;line-height:1.6;\n}\n.ioh-desc .ioh-badge{text-align:center;border-top:1px solid #232B31;padding-top:32px;margin-top:34px;}\n.ioh-desc .ioh-badge img{width:132px;margin:0 auto 20px;display:block;}\n.ioh-desc .ioh-badge .cred{\n font-family:var(--sans);font-size:18px;font-weight:700;color:var(--white);margin:0 0 6px;letter-spacing:-.005em;\n}\n.ioh-desc .ioh-badge .founder{\n font-family:var(--mono);font-size:13px;letter-spacing:.11em;text-indent:.11em;text-transform:uppercase;\n color:#7EC4E8;margin:0 0 16px;\n}\n.ioh-desc .ioh-badge .acc{\n font-family:var(--mono);font-size:12.5px;letter-spacing:.09em;text-indent:.09em;\n color:#7C878E;line-height:1.9;margin:0;\n}\n\n\/* ---------- 14. stacks ---------- *\/\n.ioh-desc .ioh-stacks{display:grid;grid-template-columns:repeat(3,1fr);gap:20px;margin-top:32px;}\n.ioh-desc .ioh-scard{\n border:1px solid var(--silver-light);border-radius:14px;padding:26px 22px;background:var(--white);\n}\n.ioh-desc .ioh-scard .sk{\n font-family:var(--mono);font-size:12.5px;font-weight:600;letter-spacing:.11em;\n text-transform:uppercase;color:var(--blue);display:block;margin-bottom:10px;\n}\n.ioh-desc .ioh-scard h3{font-size:19px;}\n.ioh-desc .ioh-scard p{font-size:16.5px;margin:0;}\n\n\/* ---------- 15. sign-off ---------- *\/\n.ioh-desc .ioh-signoff{text-align:center;padding:52px 26px;background:var(--silver-pale);border-bottom:1px solid var(--silver-light);}\n.ioh-desc .ioh-signoff .line{\n font-family:var(--serif);font-size:clamp(19px,2.1vw,22px);line-height:1.55;color:var(--ink);\n max-width:620px;margin:0 auto 26px;\n}\n.ioh-desc .ioh-signoff .stay{\n font-family:var(--mono);font-size:13.5px;font-weight:600;letter-spacing:.16em;text-indent:.16em;\n text-transform:uppercase;color:var(--muted);margin:0 0 10px;\n}\n.ioh-desc .ioh-signoff .sig{\n font-family:var(--serif);font-style:italic;font-size:32px;font-weight:500;color:var(--blue-dark);\n line-height:1.2;margin:0 0 12px;\n}\n.ioh-desc .ioh-signoff .sigcred{\n font-family:var(--mono);font-size:12.5px;letter-spacing:.1em;text-indent:.1em;\n color:var(--muted);margin:0;\n}\n\n\/* ---------- 16. faq ---------- *\/\n.ioh-desc .ioh-faq{max-width:820px;margin:30px auto 0;}\n.ioh-desc details{border-bottom:1px solid var(--silver-light);}\n.ioh-desc summary{\n cursor:pointer;list-style:none;padding:19px 44px 19px 0;position:relative;\n font-family:var(--sans);font-size:18px;font-weight:700;color:var(--ink);line-height:1.4;\n}\n.ioh-desc summary::-webkit-details-marker{display:none;}\n.ioh-desc summary::after{\n content:\"+\";position:absolute;right:6px;top:17px;color:var(--blue);\n font-size:24px;font-weight:400;line-height:1.2;\n}\n.ioh-desc details[open] summary::after{content:\"–\";}\n.ioh-desc .ioh-ans{padding:0 0 22px;}\n.ioh-desc .ioh-ans p{font-size:17.5px;}\n.ioh-desc .ioh-ans ul{margin:0 0 12px;padding-left:20px;}\n.ioh-desc .ioh-ans li{font-size:17.5px;line-height:1.55;margin-bottom:8px;}\n\n\/* ---------- 17. close ---------- *\/\n.ioh-desc .ioh-close{background:var(--blue);padding:64px 26px;text-align:center;}\n.ioh-desc .ioh-close h2{color:var(--white);max-width:820px;margin:0 auto 20px;}\n.ioh-desc .ioh-close p{color:#E4F1F8;font-size:19px;max-width:700px;margin:0 auto 14px;}\n.ioh-desc .ioh-close p:last-child{margin-bottom:0;}\n.ioh-desc .ioh-close .kicker{\n font-family:var(--mono);font-size:13px;font-weight:600;letter-spacing:.16em;text-indent:.16em;\n text-transform:uppercase;color:#BFE2F3;margin:0 0 16px;\n}\n\n\/* ---------- 18. footer ---------- *\/\n.ioh-desc .ioh-footer{background:var(--silver-pale);padding:38px 26px;}\n.ioh-desc .ioh-footer p{\n font-size:12.5px;line-height:1.75;color:var(--muted);max-width:900px;margin:0 auto 12px;\n text-align:center;font-family:var(--sans);\n}\n.ioh-desc .ioh-footer p:last-child{margin-bottom:0;}\n.ioh-desc .ioh-footer .disc{\n border-top:1px solid var(--silver-light);padding-top:16px;margin-top:18px;font-style:italic;\n}\n\n\/* ---------- responsive ---------- *\/\n@media (max-width:960px){\n .ioh-desc .ioh-bgrid,.ioh-desc .ioh-quad{grid-template-columns:1fr 1fr;}\n .ioh-desc .ioh-qcell:nth-child(2){border-right:0;}\n .ioh-desc .ioh-qcell:nth-child(1),.ioh-desc .ioh-qcell:nth-child(2){border-bottom:1px solid var(--silver-light);}\n .ioh-desc .ioh-supply,.ioh-desc .ioh-tl,.ioh-desc .ioh-stacks,.ioh-desc .ioh-qgrid{grid-template-columns:1fr;}\n .ioh-desc .ioh-proof{grid-template-columns:1fr;}\n .ioh-desc .ioh-brow{grid-template-columns:1fr;}\n .ioh-desc .ioh-loop{grid-template-columns:1fr;}\n .ioh-desc .ioh-conn{padding:8px 0;}\n .ioh-desc .ioh-conn::before{content:\"\\2193\";}\n .ioh-desc .ioh-mgrid{grid-template-columns:1fr;}\n .ioh-desc .ioh-bl{border-right:0;border-bottom:1px solid var(--silver-light);}\n}\n@media (max-width:680px){\n .ioh-desc{font-size:17px;}\n .ioh-desc p{font-size:17px;}\n .ioh-desc .ioh-sec,.ioh-desc .ioh-dark,.ioh-desc .ioh-band,.ioh-desc .ioh-close{padding:44px 18px;}\n .ioh-desc .ioh-mast{padding:44px 18px 38px;}\n .ioh-desc .ioh-chips{grid-template-columns:1fr 1fr;}\n .ioh-desc .ioh-two,.ioh-desc .ioh-bgrid{grid-template-columns:1fr;}\n .ioh-desc .ioh-quad{grid-template-columns:1fr;}\n .ioh-desc .ioh-qcell{border-right:0;border-bottom:1px solid var(--silver-light);}\n .ioh-desc .ioh-qcell:last-child{border-bottom:0;}\n .ioh-desc .ioh-ing{grid-template-columns:1fr;gap:12px;}\n .ioh-desc .ioh-footer{padding:30px 18px;}\n}\n@media (prefers-reduced-motion:reduce){\n .ioh-desc *{transition:none!important;animation:none!important;}\n}\n\u003c\/style\u003e\n\n\u003c!-- ============ 1. MASTHEAD ============ --\u003e\n\u003csection class=\"ioh-mast\"\u003e\n \u003cdiv class=\"ioh-wrap\"\u003e\n \u003cp class=\"ioh-eyebrow\"\u003eIOH Nutrition — Methylation Support\u003c\/p\u003e\n \u003ch1\u003eTMG Tri-Methyl Complex\u003c\/h1\u003e\n \u003cp class=\"ioh-sub\"\u003eThe concentrated tier. Active, coenzyme-form B vitamins plus a betaine methyl donor, in one capsule a day.\u003c\/p\u003e\n \u003cdiv class=\"ioh-rule\"\u003e\u003c\/div\u003e\n \u003cp class=\"ioh-lead\"\u003eMethylation is the quiet housekeeping your cells run every second of every day — building neurotransmitters, recycling homocysteine, switching genes on and off, keeping the liver's detoxification machinery supplied. It only works if the raw materials show up in a form the body can use immediately. We built this formula out of the forms that don't wait in line for conversion.\u003c\/p\u003e\n \u003cdiv class=\"ioh-chips\"\u003e\n \u003cdiv class=\"ioh-chip\"\u003e\n\u003cspan class=\"n\"\u003e8\u003c\/span\u003e\u003cspan class=\"l\"\u003eActives per capsule\u003c\/span\u003e\n\u003c\/div\u003e\n \u003cdiv class=\"ioh-chip\"\u003e\n\u003cspan class=\"n\"\u003e14\u003c\/span\u003e\u003cspan class=\"l\"\u003eDistinct nutrient forms\u003c\/span\u003e\n\u003c\/div\u003e\n \u003cdiv class=\"ioh-chip\"\u003e\n\u003cspan class=\"n\"\u003e1\u003c\/span\u003e\u003cspan class=\"l\"\u003eCapsule daily\u003c\/span\u003e\n\u003c\/div\u003e\n \u003cdiv class=\"ioh-chip\"\u003e\n\u003cspan class=\"n\"\u003e0\u003c\/span\u003e\u003cspan class=\"l\"\u003eFolic acid or cyanocobalamin\u003c\/span\u003e\n\u003c\/div\u003e\n \u003c\/div\u003e\n \u003c\/div\u003e\n\u003c\/section\u003e\n\n\u003c!-- ============ 2. LEAD ARGUMENT ============ --\u003e\n\u003csection class=\"ioh-sec\"\u003e\n \u003cdiv class=\"ioh-narrow\"\u003e\n \u003cp class=\"ioh-eyebrow\"\u003eThe problem with most B complexes\u003c\/p\u003e\n \u003ch2\u003eA vitamin your body can't convert is a vitamin your body doesn't have.\u003c\/h2\u003e\n \u003cp\u003eMost B-complex products are built from the cheapest, most shelf-stable version of each vitamin. Folic acid instead of folate. Cyanocobalamin instead of the two forms of B12 your cells actually run on. Pyridoxine instead of the phosphorylated form the enzymes bind. Thiamine mononitrate, because it costs almost nothing.\u003c\/p\u003e\n \u003cp\u003eThose forms are not useless. They are simply raw material. Before any of them can participate in a single reaction, your body has to convert them — a multi-step enzymatic process that depends on other nutrients, on liver capacity, on gut absorption, and on the genetics you were handed. The MTHFR polymorphisms are the best-known example, common enough that a large share of the population carries at least one copy, and they reduce how efficiently the body converts folate into its usable methyl form.\u003c\/p\u003e\n \u003cp\u003eThis is why the same B complex produces obvious results in one person and nothing at all in another. The label was identical. The conversion capacity wasn't.\u003c\/p\u003e\n \u003cp\u003eWe formulated TMG Tri-Methyl Complex to remove the conversion step wherever a usable form exists. Two forms of folate, including crystalline L-5-methylfolate. Two forms of B12, methylcobalamin and adenosylcobalamin. B6 as pyridoxal 5-phosphate. B2 as riboflavin 5-phosphate. Three forms of B1, two of which are built to cross membranes that plain thiamine struggles with. Then betaine, so the methylation cycle has a second route to run on when the folate route is congested.\u003c\/p\u003e\n \u003c\/div\u003e\n\u003c\/section\u003e\n\n\u003c!-- ============ 2b. METHYLATION MAP — EDUCATIONAL INFOGRAPHIC ============ --\u003e\n\u003csection class=\"ioh-sec\"\u003e\n \u003cdiv class=\"ioh-wrap\"\u003e\n \u003cp class=\"ioh-eyebrow\"\u003eThe map\u003c\/p\u003e\n \u003ch2\u003eMethylation in one picture, with every nutrient in this capsule marked on it.\u003c\/h2\u003e\n \u003cp class=\"ioh-lead\"\u003eMethylation gets discussed as if it were a mood or a personality trait. It is not. It is a loop, it runs in one direction, and every step of it either has the nutrient it needs or it does not. Here is the whole thing, and here is exactly where the fourteen forms in this capsule enter it.\u003c\/p\u003e\n\n \u003cdiv class=\"ioh-map\"\u003e\n \u003cdiv class=\"ioh-mhead\"\u003e\n \u003cp class=\"mt\"\u003eThe methionine cycle\u003c\/p\u003e\n \u003cp class=\"mb\"\u003eIOH Nutrition — Educational\u003c\/p\u003e\n \u003c\/div\u003e\n\n \u003cdiv class=\"ioh-mstage\"\u003e\n \u003cp class=\"ioh-mlabel\"\u003ePart one — The loop, in four steps\u003c\/p\u003e\n \u003cdiv class=\"ioh-loop\"\u003e\n \u003cdiv class=\"ioh-node\"\u003e\n \u003cspan class=\"nn\"\u003e01\u003c\/span\u003e\n \u003cspan class=\"nt\"\u003eMethionine\u003c\/span\u003e\n \u003cp\u003eAn essential amino acid you get from dietary protein. It is the entry point to the entire cycle and the form your body has to keep regenerating.\u003c\/p\u003e\n \u003c\/div\u003e\n \u003cdiv class=\"ioh-conn\" aria-hidden=\"true\"\u003e\u003c\/div\u003e\n \u003cdiv class=\"ioh-node\"\u003e\n \u003cspan class=\"nn\"\u003e02\u003c\/span\u003e\n \u003cspan class=\"nt\"\u003eSAMe\u003c\/span\u003e\n \u003cp\u003eMethionine gets activated into S-adenosylmethionine, the universal methyl donor. The enzyme that does it, MAT, is magnesium-dependent.\u003c\/p\u003e\n \u003c\/div\u003e\n \u003cdiv class=\"ioh-conn\" aria-hidden=\"true\"\u003e\u003c\/div\u003e\n \u003cdiv class=\"ioh-node\"\u003e\n \u003cspan class=\"nn\"\u003e03\u003c\/span\u003e\n \u003cspan class=\"nt\"\u003eSAH\u003c\/span\u003e\n \u003cp\u003eSAMe hands its methyl group to one of more than two hundred methyltransferases and becomes S-adenosylhomocysteine. This step is the spending.\u003c\/p\u003e\n \u003c\/div\u003e\n \u003cdiv class=\"ioh-conn\" aria-hidden=\"true\"\u003e\u003c\/div\u003e\n \u003cdiv class=\"ioh-node\"\u003e\n \u003cspan class=\"nn\"\u003e04\u003c\/span\u003e\n \u003cspan class=\"nt\"\u003eHomocysteine\u003c\/span\u003e\n \u003cp\u003eSAH is hydrolyzed to homocysteine. This is the junction, and it is the number your physician measures. It is not a toxin — it is a normal intermediate that has to keep moving.\u003c\/p\u003e\n \u003c\/div\u003e\n \u003c\/div\u003e\n \u003cp class=\"ioh-mnote\"\u003eEverything past this point is about getting homocysteine out of the junction. It has two ways back to methionine and one way out of the cycle entirely, and which of them are working depends on which nutrients are present.\u003c\/p\u003e\n \u003c\/div\u003e\n\n \u003cdiv class=\"ioh-mstage alt\"\u003e\n \u003cp class=\"ioh-mlabel\"\u003ePart two — Back to methionine, by two independent routes\u003c\/p\u003e\n \u003cdiv class=\"ioh-mgrid\"\u003e\n \u003cdiv class=\"ioh-mcard\"\u003e\n \u003cspan class=\"mk\"\u003eReturn route A\u003c\/span\u003e\n \u003ch3\u003eThe folate route\u003c\/h3\u003e\n \u003cspan class=\"enz\"\u003eMTHFR converts folate to 5-MTHF, using FAD from riboflavin.\u003cbr\u003eMethionine synthase then transfers the methyl group, using B12.\u003c\/span\u003e\n \u003cp\u003eThe main route in most tissues, and the one MTHFR variants constrain — because MTHFR is the enzyme that makes the methylfolate the next step needs. Riboflavin is the cofactor for MTHFR itself, which is why a methylation formula without functional B2 is fueling a machine and leaving out a bearing.\u003c\/p\u003e\n \u003cul class=\"ioh-chips2\"\u003e\n \u003cli\u003eFolate 3,400 mcg DFE\u003c\/li\u003e\n \u003cli\u003eL-5-MTHF (Magnafolate C)\u003c\/li\u003e\n \u003cli\u003eCalcium folinate\u003c\/li\u003e\n \u003cli\u003eMethylcobalamin 1,000 mcg\u003c\/li\u003e\n \u003cli\u003eRiboflavin 5-phosphate\u003c\/li\u003e\n \u003c\/ul\u003e\n \u003c\/div\u003e\n \u003cdiv class=\"ioh-mcard\"\u003e\n \u003cspan class=\"mk\"\u003eReturn route B\u003c\/span\u003e\n \u003ch3\u003eThe betaine route\u003c\/h3\u003e\n \u003cspan class=\"enz\"\u003eBHMT transfers a methyl group directly from betaine.\u003cbr\u003eNo folate and no B12 required. Zinc-dependent enzyme.\u003c\/span\u003e\n \u003cp\u003eThe parallel route, concentrated in liver and kidney. Betaine carries three methyl groups and donates one straight to homocysteine, which means this lane keeps running even when the folate lane is constrained by genetics or low intake. A formula carrying only folate and B12 is supplying one lane and calling it a highway.\u003c\/p\u003e\n \u003cul class=\"ioh-chips2\"\u003e\n \u003cli\u003eBetaine anhydrous (TMG) 400 mg\u003c\/li\u003e\n \u003cli class=\"out\"\u003eBelow research range — see the dose ledger\u003c\/li\u003e\n \u003cli class=\"out\"\u003eZinc — from minerals, not this capsule\u003c\/li\u003e\n \u003c\/ul\u003e\n \u003c\/div\u003e\n \u003c\/div\u003e\n \u003c\/div\u003e\n\n \u003cdiv class=\"ioh-mstage\"\u003e\n \u003cp class=\"ioh-mlabel\"\u003ePart three — The off-ramp, for the homocysteine that should not be recycled\u003c\/p\u003e\n \u003cdiv class=\"ioh-mgrid\"\u003e\n \u003cdiv class=\"ioh-mcard ramp\"\u003e\n \u003cspan class=\"mk\"\u003eExit route C\u003c\/span\u003e\n \u003ch3\u003eTranssulfuration\u003c\/h3\u003e\n \u003cspan class=\"enz\"\u003eCBS commits homocysteine downstream.\u003cbr\u003eCTH completes it. Both enzymes require B6 as P5P.\u003c\/span\u003e\n \u003cp\u003eNot every molecule should go back to methionine. Some has to leave the cycle for good, and this is the door. Both enzymes on it are B6-dependent, which is why B6 form and adequacy matter here as much as folate form matters upstream.\u003c\/p\u003e\n \u003cul class=\"ioh-chips2\"\u003e\n \u003cli\u003ePyridoxal 5-phosphate 25 mg\u003c\/li\u003e\n \u003cli\u003ePyridoxine HCl 25 mg\u003c\/li\u003e\n \u003c\/ul\u003e\n \u003c\/div\u003e\n \u003cdiv class=\"ioh-mcard ramp\"\u003e\n \u003cspan class=\"mk\"\u003eDownstream of exit C\u003c\/span\u003e\n \u003ch3\u003eCysteine, then glutathione\u003c\/h3\u003e\n \u003cspan class=\"enz\"\u003eCystathionine to cysteine to glutathione.\u003c\/span\u003e\n \u003cp\u003eThe off-ramp ends at cysteine, and cysteine is the rate-limiting input for glutathione, the body's primary intracellular antioxidant. This is the mechanical link between methylation and the detoxification side of functional medicine, and it is a real link rather than a marketing one.\u003c\/p\u003e\n \u003cul class=\"ioh-chips2\"\u003e\n \u003cli class=\"out\"\u003eCysteine — see the NAC pairing below\u003c\/li\u003e\n \u003c\/ul\u003e\n \u003c\/div\u003e\n \u003c\/div\u003e\n \u003c\/div\u003e\n\n \u003cdiv class=\"ioh-mfoot\"\u003e\n \u003cspan class=\"ioh-key\"\u003e\u003ci\u003e\u003c\/i\u003e Supplied by this capsule, at the dose shown\u003c\/span\u003e\n \u003cspan class=\"ioh-key\"\u003e\u003ci class=\"out\"\u003e\u003c\/i\u003e Required by the pathway, not supplied here\u003c\/span\u003e\n \u003c\/div\u003e\n \u003c\/div\u003e\n\n \u003cp class=\"ioh-mnote\"\u003eEducational illustration of a normal metabolic pathway. It is not a claim that this or any dietary supplement treats, prevents or cures a disease. Enzyme names are given so you can look the chemistry up yourself rather than take our word for it.\u003c\/p\u003e\n \u003c\/div\u003e\n\u003c\/section\u003e\n\n\u003c!-- ============ 3. THE DIFFERENCE ============ --\u003e\n\u003csection class=\"ioh-sec\"\u003e\n \u003cdiv class=\"ioh-wrap\"\u003e\n \u003cp class=\"ioh-eyebrow\"\u003eThe difference\u003c\/p\u003e\n \u003ch2\u003eSame eight nutrients. Entirely different chemistry.\u003c\/h2\u003e\n \u003cp class=\"ioh-lead\"\u003eTwo products can list the same vitamins and deliver completely different biology. The form on the label is the whole argument.\u003c\/p\u003e\n \u003cdiv class=\"ioh-two\"\u003e\n \u003cdiv class=\"ioh-col std\"\u003e\n \u003cspan class=\"tag\"\u003eThe category standard\u003c\/span\u003e\n \u003ch3\u003eWhat is usually in the bottle\u003c\/h3\u003e\n \u003cul\u003e\n \u003cli\u003eFolic acid, which requires multi-step conversion and can accumulate unmetabolized in circulation\u003c\/li\u003e\n \u003cli\u003eCyanocobalamin, a synthetic B12 that carries a cyanide molecule the body has to cleave off and clear\u003c\/li\u003e\n \u003cli\u003eOne form of each vitamin, chosen on cost and shelf life\u003c\/li\u003e\n \u003cli\u003ePyridoxine hydrochloride alone, with no phosphorylated B6\u003c\/li\u003e\n \u003cli\u003eThiamine mononitrate, poorly suited to lipid membranes\u003c\/li\u003e\n \u003cli\u003eNo second methyl donor. The folate route is the only route\u003c\/li\u003e\n \u003cli\u003eProprietary blends that hide individual amounts\u003c\/li\u003e\n \u003c\/ul\u003e\n \u003c\/div\u003e\n \u003cdiv class=\"ioh-col ioh\"\u003e\n \u003cspan class=\"tag\"\u003eThe IOH standard\u003c\/span\u003e\n \u003ch3\u003eWhat we put in this one\u003c\/h3\u003e\n \u003cul\u003e\n \u003cli\u003eCalcium folinate plus crystalline L-5-methylfolate calcium — 3,400 mcg DFE from two distinct entry points\u003c\/li\u003e\n \u003cli\u003eMethylcobalamin plus adenosylcobalamin — the cytosolic and mitochondrial forms, both present\u003c\/li\u003e\n \u003cli\u003eCoenzyme forms wherever one exists: riboflavin 5-phosphate, pyridoxal 5-phosphate\u003c\/li\u003e\n \u003cli\u003eBoth P5P and pyridoxine HCl, because they don't enter tissues the same way\u003c\/li\u003e\n \u003cli\u003eThree thiamine forms, including TTFD and benfotiamine, built for lipid-rich tissue\u003c\/li\u003e\n \u003cli\u003e400 mg betaine anhydrous, opening a second remethylation route that runs independent of folate\u003c\/li\u003e\n \u003cli\u003eEvery active disclosed at its dose. No blends, no hiding\u003c\/li\u003e\n \u003c\/ul\u003e\n \u003c\/div\u003e\n \u003c\/div\u003e\n \u003c\/div\u003e\n\u003c\/section\u003e\n\n\u003c!-- ============ 4. DARK BENEFITS GRID ============ --\u003e\n\u003csection class=\"ioh-dark\"\u003e\n \u003cdiv class=\"ioh-wrap\"\u003e\n \u003cp class=\"ioh-eyebrow on-dark\"\u003eWhat this formula supports\u003c\/p\u003e\n \u003ch2 class=\"on-dark\"\u003eFour jobs, one capsule.\u003c\/h2\u003e\n \u003cp class=\"ioh-lead\"\u003eStructure and function support, stated plainly and without exaggeration.\u003c\/p\u003e\n \u003cdiv class=\"ioh-bgrid\"\u003e\n \u003cdiv class=\"ioh-bcard\"\u003e\n \u003cspan class=\"num\"\u003e01\u003c\/span\u003e\n \u003ch3\u003eHealthy methylation\u003c\/h3\u003e\n \u003cp\u003eSupplies methyl groups and the cofactors that move them, supporting the body's normal methylation and demethylation processes.\u003c\/p\u003e\n \u003c\/div\u003e\n \u003cdiv class=\"ioh-bcard\"\u003e\n \u003cspan class=\"num\"\u003e02\u003c\/span\u003e\n \u003ch3\u003eHomocysteine metabolism\u003c\/h3\u003e\n \u003cp\u003eSupports the body's normal conversion of homocysteine back to methionine, helping maintain homocysteine levels already within a healthy range.\u003c\/p\u003e\n \u003c\/div\u003e\n \u003cdiv class=\"ioh-bcard\"\u003e\n \u003cspan class=\"num\"\u003e03\u003c\/span\u003e\n \u003ch3\u003eEnergy metabolism and nerve health\u003c\/h3\u003e\n \u003cp\u003eB1, B2, B5, B6 and B12 are required cofactors in normal cellular energy production and in supporting healthy nervous system function.\u003c\/p\u003e\n \u003c\/div\u003e\n \u003cdiv class=\"ioh-bcard\"\u003e\n \u003cspan class=\"num\"\u003e04\u003c\/span\u003e\n \u003ch3\u003eBuilt for reduced conversion capacity\u003c\/h3\u003e\n \u003cp\u003eFormulated with active and coenzyme forms for people who carry MTHFR variants or simply want the forms that skip the conversion step.\u003c\/p\u003e\n \u003c\/div\u003e\n \u003c\/div\u003e\n \u003c\/div\u003e\n\u003c\/section\u003e\n\n\u003c!-- ============ 5. SIGNATURE SECTION: THREE ROUTES ============ --\u003e\n\u003csection class=\"ioh-sec\"\u003e\n \u003cdiv class=\"ioh-wrap\"\u003e\n \u003cp class=\"ioh-eyebrow\"\u003eThe methyl budget\u003c\/p\u003e\n \u003ch2\u003eMethyl groups are a budget. Most of yours is already committed.\u003c\/h2\u003e\n \u003cp class=\"ioh-lead\"\u003eEvery methylation conversation focuses on supply — folate, B12, betaine, the forms, the doses. Almost nobody talks about the demand side. Look back at step 03 on the map above — the moment SAMe hands off its methyl group and becomes SAH. That step is the spending, and it happens constantly. The spending is not evenly distributed, and it is not optional. Understanding where it goes is the difference between guessing at a methylation product and choosing one.\u003c\/p\u003e\n\n \u003cdiv class=\"ioh-budget\"\u003e\n \u003cdiv class=\"ioh-brow\"\u003e\n \u003cdiv class=\"ioh-bl\"\u003e\n \u003cspan class=\"bk\"\u003eLine item 01\u003c\/span\u003e\n \u003cspan class=\"bn\"\u003eCreatine synthesis\u003c\/span\u003e\n \u003cspan class=\"be\"\u003eEnzyme: GAMT\u003c\/span\u003e\n \u003c\/div\u003e\n \u003cdiv class=\"ioh-br\"\u003e\n \u003cdiv class=\"ioh-bar\"\u003e\u003ci class=\"l1\"\u003e\u003c\/i\u003e\u003c\/div\u003e\n \u003cp class=\"ioh-bw\"\u003eThe largest single draw\u003c\/p\u003e\n \u003cp\u003eThe final step in making creatine is a methylation, and it is widely described as the biggest consumer of labile methyl groups in the body. Every gram of creatine your body builds itself is paid for out of this budget. This is also the one line item you can reduce from the outside, which is why creatine appears in the stack section below and why it belongs there on chemistry rather than on convenience.\u003c\/p\u003e\n \u003c\/div\u003e\n \u003c\/div\u003e\n \u003cdiv class=\"ioh-brow\"\u003e\n \u003cdiv class=\"ioh-bl\"\u003e\n \u003cspan class=\"bk\"\u003eLine item 02\u003c\/span\u003e\n \u003cspan class=\"bn\"\u003ePhosphatidylcholine synthesis\u003c\/span\u003e\n \u003cspan class=\"be\"\u003eEnzyme: PEMT\u003c\/span\u003e\n \u003c\/div\u003e\n \u003cdiv class=\"ioh-br\"\u003e\n \u003cdiv class=\"ioh-bar\"\u003e\u003ci class=\"l2\"\u003e\u003c\/i\u003e\u003c\/div\u003e\n \u003cp class=\"ioh-bw\"\u003eMajor draw, concentrated in liver\u003c\/p\u003e\n \u003cp\u003eBuilding phosphatidylcholine from phosphatidylethanolamine takes three consecutive methyl groups per molecule. It is how the liver packages fat for export and how cell membranes get built. This is the reason methyl-group availability and normal liver fat metabolism keep turning up in the same paragraph.\u003c\/p\u003e\n \u003c\/div\u003e\n \u003c\/div\u003e\n \u003cdiv class=\"ioh-brow\"\u003e\n \u003cdiv class=\"ioh-bl\"\u003e\n \u003cspan class=\"bk\"\u003eLine item 03\u003c\/span\u003e\n \u003cspan class=\"bn\"\u003eCatecholamine processing\u003c\/span\u003e\n \u003cspan class=\"be\"\u003eEnzyme: COMT\u003c\/span\u003e\n \u003c\/div\u003e\n \u003cdiv class=\"ioh-br\"\u003e\n \u003cdiv class=\"ioh-bar\"\u003e\u003ci class=\"l3\"\u003e\u003c\/i\u003e\u003c\/div\u003e\n \u003cp class=\"ioh-bw\"\u003eOngoing, and the one you may notice\u003c\/p\u003e\n \u003cp\u003eDopamine, norepinephrine and epinephrine are cleared by methylation. That is the mechanism behind why a subset of people feel noticeably different — sometimes more alert, occasionally too alert — when methyl donors arrive in quantity. It is also why we tell you to start slowly if you have reacted to methylated B vitamins before.\u003c\/p\u003e\n \u003c\/div\u003e\n \u003c\/div\u003e\n \u003cdiv class=\"ioh-brow\"\u003e\n \u003cdiv class=\"ioh-bl\"\u003e\n \u003cspan class=\"bk\"\u003eLine item 04\u003c\/span\u003e\n \u003cspan class=\"bn\"\u003eDNA and histone methylation\u003c\/span\u003e\n \u003cspan class=\"be\"\u003eEnzymes: DNMTs, HMTs\u003c\/span\u003e\n \u003c\/div\u003e\n \u003cdiv class=\"ioh-br\"\u003e\n \u003cdiv class=\"ioh-bar\"\u003e\u003ci class=\"l4\"\u003e\u003c\/i\u003e\u003c\/div\u003e\n \u003cp class=\"ioh-bw\"\u003eSmall in volume, large in consequence\u003c\/p\u003e\n \u003cp\u003eThe smallest line on the budget by sheer quantity of methyl groups, and the one everybody means when they say methylation affects gene expression. It draws from the same pool as the three above it, which is the entire point: the flashy job competes for the same currency as the routine ones.\u003c\/p\u003e\n \u003c\/div\u003e\n \u003c\/div\u003e\n \u003cdiv class=\"ioh-brow\"\u003e\n \u003cdiv class=\"ioh-bl\"\u003e\n \u003cspan class=\"bk\"\u003eEverything else\u003c\/span\u003e\n \u003cspan class=\"bn\"\u003eCarnitine, melatonin, phospholipid repair, and more\u003c\/span\u003e\n \u003cspan class=\"be\"\u003eDozens of methyltransferases\u003c\/span\u003e\n \u003c\/div\u003e\n \u003cdiv class=\"ioh-br\"\u003e\n \u003cdiv class=\"ioh-bar\"\u003e\u003ci class=\"l4\"\u003e\u003c\/i\u003e\u003c\/div\u003e\n \u003cp class=\"ioh-bw\"\u003eContinuous background spending\u003c\/p\u003e\n \u003cp\u003eMore than two hundred human enzymes use SAMe as their methyl source. None of them file a request. They spend whatever is available, all day, whether or not the supply side is keeping up.\u003c\/p\u003e\n \u003c\/div\u003e\n \u003c\/div\u003e\n \u003c\/div\u003e\n \u003cp class=\"ioh-bnote\"\u003eBar lengths show relative ordering, not measured proportions. The actual split varies by tissue, diet, species and study method, and we are not going to print a percentage we cannot source for you. What is well established is the ordering — creatine and phosphatidylcholine synthesis dominate the budget, and gene-level methylation draws from the same pool.\u003c\/p\u003e\n\n \u003cdiv class=\"ioh-supply\"\u003e\n \u003cdiv class=\"ioh-sside\"\u003e\n \u003cspan class=\"sh\"\u003eThe supply side\u003c\/span\u003e\n \u003ch3\u003eWhat this capsule is\u003c\/h3\u003e\n \u003cp\u003eFolate and B12 in their coenzyme forms to run remethylation, riboflavin so the MTHFR enzyme has its own cofactor, betaine as a second methyl donor that works without folate or B12, and P5P for the transsulfuration exit that lets homocysteine leave the cycle entirely. That is the supply side, delivered in the forms that do not wait on a conversion step.\u003c\/p\u003e\n \u003c\/div\u003e\n \u003cdiv class=\"ioh-sside dem\"\u003e\n \u003cspan class=\"sh\"\u003eThe demand side\u003c\/span\u003e\n \u003ch3\u003eWhat most products ignore\u003c\/h3\u003e\n \u003cp\u003eYou can supply methyl groups perfectly and still run tight if the budget is fully committed. Reducing demand is the other half of the equation, and there is exactly one line item on the list above that you can reduce from the outside. That is the mechanistic reason for the first stack recommendation on this page, and it is not a cross-sell dressed up as science.\u003c\/p\u003e\n \u003c\/div\u003e\n \u003c\/div\u003e\n\n \u003cdiv class=\"ioh-straight\"\u003e\n \u003cspan class=\"st\"\u003eStraight talk about the TMG dose\u003c\/span\u003e\n \u003cp\u003eThe bottle says TMG on the front, so we owe you an honest number. Clinical work on betaine and homocysteine has generally used doses from roughly 500 mg up to several grams per day, with much of the published research clustered at 1.5 g and above. This capsule contains 400 mg. That is below the range most of that research used, and we are not going to borrow a result from a 3-gram study and print it next to a 400 mg dose.\u003c\/p\u003e\n \u003cp\u003eHere is what 400 mg is actually for. It keeps the betaine route supplied rather than empty, and it does that alongside a genuinely complete set of active-form cofactors for the folate route and the transsulfuration exit. \u003cstrong\u003eThis is a methylation cofactor formula with a betaine assist, not a betaine dose product.\u003c\/strong\u003e And here is the part nobody in this category will tell you: a real betaine dose cannot come in a capsule at all. The published range is roughly 1.5 to 3 grams a day, and 1.5 grams of betaine on its own fills about two capsules with nothing else in them. Any product promising you a clinical betaine dose in a capsule alongside a full B-complex is doing arithmetic it hopes you will not check. If a betaine intake in that range is what you and your practitioner are after, that is a powder-form conversation. What fits in one capsule is the cofactor side, and that is what we built.\u003c\/p\u003e\n \u003c\/div\u003e\n \u003c\/div\u003e\n\u003c\/section\u003e\n\n\u003c!-- ============ 6. INSIDE THE FORMULA ============ --\u003e\n\u003csection class=\"ioh-sec\"\u003e\n \u003cdiv class=\"ioh-wrap\"\u003e\n \u003cp class=\"ioh-eyebrow\"\u003eInside the formula\u003c\/p\u003e\n \u003ch2\u003eEvery active, every form, every dose.\u003c\/h2\u003e\n \u003cp class=\"ioh-lead\"\u003eEight actives delivered across fourteen distinct nutrient forms. Nothing in a blend, nothing undisclosed.\u003c\/p\u003e\n\n \u003cdiv class=\"ioh-ing\"\u003e\n \u003cdiv\u003e\n \u003cp class=\"iname\"\u003eBetaine Anhydrous (TMG)\u003c\/p\u003e\n \u003cspan class=\"idose\"\u003e400 mg\u003c\/span\u003e\n \u003cspan class=\"iform\"\u003eTrimethylglycine\u003c\/span\u003e\n \u003c\/div\u003e\n \u003cdiv\u003e\n \u003cp\u003eThree methyl groups attached to a glycine backbone, which is exactly what the name describes. Betaine donates one of those methyl groups through the BHMT enzyme, a route that runs independent of folate and B12 and is concentrated in the liver and kidney.\u003c\/p\u003e\n \u003cp\u003eSupports healthy methylation and the body's normal homocysteine metabolism. It also participates in normal liver fat metabolism. See the note above on where 400 mg sits relative to published research doses.\u003c\/p\u003e\n \u003c\/div\u003e\n \u003c\/div\u003e\n\n \u003cdiv class=\"ioh-ing\"\u003e\n \u003cdiv\u003e\n \u003cp class=\"iname\"\u003eFolate\u003c\/p\u003e\n \u003cspan class=\"idose\"\u003e3,400 mcg DFE (2,000 mcg folate)\u003c\/span\u003e\n \u003cspan class=\"iform\"\u003e1,000 mcg folinic acid from calcium folinate + 1,000 mcg L-5-methyltetrahydrofolate calcium (Magnafolate C)\u003c\/span\u003e\n \u003c\/div\u003e\n \u003cdiv\u003e\n \u003cp\u003eTwo folates, not one, because they enter the folate pool at different points. L-5-methylfolate is the finished methyl-donating form, the one that requires no MTHFR activity to become useful. Magnafolate C is a crystalline calcium salt of L-5-MTHF, a form selected for stability, since non-crystalline methylfolate degrades comparatively quickly on the shelf.\u003c\/p\u003e\n \u003cp\u003eFolinic acid enters upstream and feeds the wider folate pool used for DNA synthesis and repair, which methylfolate alone does not fully cover. Neither is folic acid, and that is deliberate.\u003c\/p\u003e\n \u003c\/div\u003e\n \u003c\/div\u003e\n\n \u003cdiv class=\"ioh-ing\"\u003e\n \u003cdiv\u003e\n \u003cp class=\"iname\"\u003eVitamin B12\u003c\/p\u003e\n \u003cspan class=\"idose\"\u003e1,500 mcg\u003c\/span\u003e\n \u003cspan class=\"iform\"\u003e1,000 mcg methylcobalamin + 500 mcg adenosylcobalamin\u003c\/span\u003e\n \u003c\/div\u003e\n \u003cdiv\u003e\n \u003cp\u003eThe two coenzyme forms your body actually uses, in the two places it uses them. Methylcobalamin is the cofactor for methionine synthase in the cytosol, the enzyme that completes remethylation on the folate route. Adenosylcobalamin is the mitochondrial form, required by methylmalonyl-CoA mutase in normal energy metabolism.\u003c\/p\u003e\n \u003cp\u003eNo cyanocobalamin. Products built on cyanocobalamin ask the body to cleave off and clear a cyanide molecule before the vitamin becomes usable, then convert what remains into these same two forms.\u003c\/p\u003e\n \u003c\/div\u003e\n \u003c\/div\u003e\n\n \u003cdiv class=\"ioh-ing\"\u003e\n \u003cdiv\u003e\n \u003cp class=\"iname\"\u003eVitamin B6\u003c\/p\u003e\n \u003cspan class=\"idose\"\u003e50 mg\u003c\/span\u003e\n \u003cspan class=\"iform\"\u003e25 mg pyridoxal 5-phosphate + 25 mg pyridoxine HCl\u003c\/span\u003e\n \u003c\/div\u003e\n \u003cdiv\u003e\n \u003cp\u003ePyridoxal 5-phosphate is the active coenzyme, the form that binds directly to the more than one hundred enzymes that depend on B6 — including CBS and CGL, the two enzymes that run the transsulfuration exit out of the homocysteine pool.\u003c\/p\u003e\n \u003cp\u003ePyridoxine HCl is included alongside it rather than instead of it, because the two are handled differently on the way in and the pairing covers more ground than either alone.\u003c\/p\u003e\n \u003c\/div\u003e\n \u003c\/div\u003e\n\n \u003cdiv class=\"ioh-ing\"\u003e\n \u003cdiv\u003e\n \u003cp class=\"iname\"\u003eVitamin B1 (Thiamine)\u003c\/p\u003e\n \u003cspan class=\"idose\"\u003e50 mg\u003c\/span\u003e\n \u003cspan class=\"iform\"\u003e12.5 mg thiamine tetrahydrofurfuryl disulfide (TTFD) + 12.5 mg benfotiamine + 25 mg thiamine HCl\u003c\/span\u003e\n \u003c\/div\u003e\n \u003cdiv\u003e\n \u003cp\u003eThree forms, and the reason is membranes. Plain thiamine is water soluble and depends on a saturable transport system to get where it is going. TTFD and benfotiamine are lipid-compatible derivatives, structurally built to cross membranes that water-soluble thiamine negotiates poorly, including into nerve tissue.\u003c\/p\u003e\n \u003cp\u003eThiamine supports normal cellular energy metabolism as the cofactor for several of the enzymes that pull carbohydrate into the Krebs cycle, and supports healthy nervous system function. Almost no B complex at this price carries all three forms.\u003c\/p\u003e\n \u003c\/div\u003e\n \u003c\/div\u003e\n\n \u003cdiv class=\"ioh-ing\"\u003e\n \u003cdiv\u003e\n \u003cp class=\"iname\"\u003eVitamin B2 (Riboflavin)\u003c\/p\u003e\n \u003cspan class=\"idose\"\u003e25 mg\u003c\/span\u003e\n \u003cspan class=\"iform\"\u003e12.5 mg riboflavin + 12.5 mg riboflavin 5-phosphate\u003c\/span\u003e\n \u003c\/div\u003e\n \u003cdiv\u003e\n \u003cp\u003eThe most overlooked nutrient in the entire methylation conversation. MTHFR — the enzyme everyone worries about — is a flavoprotein. It requires FAD, a riboflavin-derived cofactor, to do its job at all. Supplying folate while running short on riboflavin is like fueling a machine and leaving out a bearing.\u003c\/p\u003e\n \u003cp\u003eRiboflavin 5-phosphate is the phosphorylated coenzyme form, included so the conversion step is not a prerequisite.\u003c\/p\u003e\n \u003c\/div\u003e\n \u003c\/div\u003e\n\n \u003cdiv class=\"ioh-ing\"\u003e\n \u003cdiv\u003e\n \u003cp class=\"iname\"\u003ePantothenic Acid (Vitamin B5)\u003c\/p\u003e\n \u003cspan class=\"idose\"\u003e25 mg\u003c\/span\u003e\n \u003cspan class=\"iform\"\u003ed-calcium pantothenate\u003c\/span\u003e\n \u003c\/div\u003e\n \u003cdiv\u003e\n \u003cp\u003eThe precursor to coenzyme A, which sits at the center of energy metabolism and is required for the normal metabolism of fats, carbohydrates and protein. Included at a supportive amount rather than a token one.\u003c\/p\u003e\n \u003c\/div\u003e\n \u003c\/div\u003e\n\n \u003cdiv class=\"ioh-ing\"\u003e\n \u003cdiv\u003e\n \u003cp class=\"iname\"\u003eBiotin (Vitamin B7)\u003c\/p\u003e\n \u003cspan class=\"idose\"\u003e50 mcg\u003c\/span\u003e\n \u003cspan class=\"iform\"\u003eBiotin USP\u003c\/span\u003e\n \u003c\/div\u003e\n \u003cdiv\u003e\n \u003cp\u003eA cofactor for the carboxylase enzymes involved in normal fat and amino acid metabolism, and it also supports healthy hair, skin and nails. Present at a nutritional amount, not a cosmetic megadose, because that is what a methylation formula calls for.\u003c\/p\u003e\n \u003c\/div\u003e\n \u003c\/div\u003e\n\n \u003ctable class=\"ioh-ledger\"\u003e\n \u003ccaption\u003eDose ledger — where each active sits, stated openly\u003c\/caption\u003e\n \u003cthead\u003e\n \u003ctr\u003e\n \u003cth scope=\"col\"\u003eActive\u003c\/th\u003e\n \u003cth scope=\"col\"\u003ePer capsule\u003c\/th\u003e\n \u003cth scope=\"col\"\u003eHow we would describe the dose\u003c\/th\u003e\n \u003c\/tr\u003e\n \u003c\/thead\u003e\n \u003ctbody\u003e\n \u003ctr\u003e\n\u003ctd\u003eBetaine anhydrous (TMG)\u003c\/td\u003e\n\u003ctd class=\"mono\"\u003e400 mg\u003c\/td\u003e\n\u003ctd\u003eBelow the range used in most published betaine and homocysteine research. Supportive, not a standalone betaine dose. Disclosed openly above.\u003c\/td\u003e\n\u003c\/tr\u003e\n \u003ctr\u003e\n\u003ctd\u003eFolate\u003c\/td\u003e\n\u003ctd class=\"mono\"\u003e3,400 mcg DFE\u003c\/td\u003e\n\u003ctd\u003eA clinical-level intake. Two forms. Well above the 400 mcg DFE Daily Value, which is why the medication and safety notes below matter.\u003c\/td\u003e\n\u003c\/tr\u003e\n \u003ctr\u003e\n\u003ctd\u003eVitamin B12\u003c\/td\u003e\n\u003ctd class=\"mono\"\u003e1,500 mcg\u003c\/td\u003e\n\u003ctd\u003eA generous oral amount, split across both coenzyme forms. Oral B12 absorption is inefficient by design, which is why amounts like this are used.\u003c\/td\u003e\n\u003c\/tr\u003e\n \u003ctr\u003e\n\u003ctd\u003eVitamin B6\u003c\/td\u003e\n\u003ctd class=\"mono\"\u003e50 mg\u003c\/td\u003e\n\u003ctd\u003eA functional amount, below the 100 mg per day adult upper intake level. Not intended for indefinite use without periodic review. See the safety note below.\u003c\/td\u003e\n\u003c\/tr\u003e\n \u003ctr\u003e\n\u003ctd\u003eVitamin B1\u003c\/td\u003e\n\u003ctd class=\"mono\"\u003e50 mg\u003c\/td\u003e\n\u003ctd\u003eWell above the Daily Value, spread across three forms so no single transport pathway has to carry it.\u003c\/td\u003e\n\u003c\/tr\u003e\n \u003ctr\u003e\n\u003ctd\u003eVitamin B2\u003c\/td\u003e\n\u003ctd class=\"mono\"\u003e25 mg\u003c\/td\u003e\n\u003ctd\u003eEnough to actually supply the MTHFR cofactor requirement rather than just satisfy the Daily Value.\u003c\/td\u003e\n\u003c\/tr\u003e\n \u003ctr\u003e\n\u003ctd\u003ePantothenic acid\u003c\/td\u003e\n\u003ctd class=\"mono\"\u003e25 mg\u003c\/td\u003e\n\u003ctd\u003eA supportive amount for coenzyme A production.\u003c\/td\u003e\n\u003c\/tr\u003e\n \u003ctr\u003e\n\u003ctd\u003eBiotin\u003c\/td\u003e\n\u003ctd class=\"mono\"\u003e50 mcg\u003c\/td\u003e\n\u003ctd\u003eA nutritional amount. Deliberately not a high-dose beauty biotin.\u003c\/td\u003e\n\u003c\/tr\u003e\n \u003c\/tbody\u003e\n \u003c\/table\u003e\n\n \u003c!-- ---- Supplement Facts panel, centered mid-page ---- --\u003e\n \u003cdiv class=\"ioh-panel-row\" style=\"margin-top:44px;\"\u003e\n \u003cdiv class=\"ioh-panel\"\u003e\n \u003cp class=\"pt\"\u003eSupplement Facts\u003c\/p\u003e\n \u003cp class=\"pmeta\"\u003eServing Size: 1 Vegetarian Capsule\u003cbr\u003eServings per Container: 30\u003c\/p\u003e\n \u003ctable\u003e\n \u003cthead\u003e\n \u003ctr class=\"hr7\"\u003e\n \u003cth scope=\"col\"\u003eAmount per Serving\u003c\/th\u003e\n \u003cth scope=\"col\" class=\"r\"\u003e\u003c\/th\u003e\n \u003cth scope=\"col\" class=\"r\"\u003e% DV\u003c\/th\u003e\n \u003c\/tr\u003e\n \u003c\/thead\u003e\n \u003ctbody\u003e\n \u003ctr\u003e\n \u003ctd\u003eThiamine (Vitamin B1)\u003cspan class=\"src\"\u003e(as Thiamine Tetrahydrofurfuryl Disulfide (TTFD) 12.5 mg, Benfotiamine 12.5 mg, and Thiamine HCl 25 mg)\u003c\/span\u003e\n\u003c\/td\u003e\n \u003ctd class=\"amt r\"\u003e50 mg\u003c\/td\u003e\n \u003ctd class=\"dv r\"\u003e4166%\u003c\/td\u003e\n \u003c\/tr\u003e\n \u003ctr\u003e\n \u003ctd\u003eRiboflavin (Vitamin B2)\u003cspan class=\"src\"\u003e(as Riboflavin 12.5 mg and Riboflavin 5-Phosphate 12.5 mg)\u003c\/span\u003e\n\u003c\/td\u003e\n \u003ctd class=\"amt r\"\u003e25 mg\u003c\/td\u003e\n \u003ctd class=\"dv r\"\u003e1923%\u003c\/td\u003e\n \u003c\/tr\u003e\n \u003ctr\u003e\n \u003ctd\u003eVitamin B6\u003cspan class=\"src\"\u003e(as 25 mg Pyridoxal 5-Phosphate and 25 mg Pyridoxine HCl)\u003c\/span\u003e\n\u003c\/td\u003e\n \u003ctd class=\"amt r\"\u003e50 mg\u003c\/td\u003e\n \u003ctd class=\"dv r\"\u003e2941%\u003c\/td\u003e\n \u003c\/tr\u003e\n \u003ctr\u003e\n \u003ctd\u003eFolate (2,000 mcg)\u003cspan class=\"src\"\u003e(as 1,000 mcg Folinic Acid from Calcium Folinate and 1,000 mcg Methyl Folate from L-5-Methyltetrahydrofolate Calcium) (Magnafolate® C)\u003c\/span\u003e\n\u003c\/td\u003e\n \u003ctd class=\"amt r\"\u003e3,400 mcg DFE\u003c\/td\u003e\n \u003ctd class=\"dv r\"\u003e850%\u003c\/td\u003e\n \u003c\/tr\u003e\n \u003ctr\u003e\n \u003ctd\u003eVitamin B12\u003cspan class=\"src\"\u003e(as 1,000 mcg Methylcobalamin and 500 mcg Adenosylcobalamin)\u003c\/span\u003e\n\u003c\/td\u003e\n \u003ctd class=\"amt r\"\u003e1,500 mcg\u003c\/td\u003e\n \u003ctd class=\"dv r\"\u003e62500%\u003c\/td\u003e\n \u003c\/tr\u003e\n \u003ctr\u003e\n \u003ctd\u003eBiotin (Vitamin B7)\u003cspan class=\"src\"\u003e(as Biotin USP)\u003c\/span\u003e\n\u003c\/td\u003e\n \u003ctd class=\"amt r\"\u003e50 mcg\u003c\/td\u003e\n \u003ctd class=\"dv r\"\u003e166%\u003c\/td\u003e\n \u003c\/tr\u003e\n \u003ctr\u003e\n \u003ctd\u003ePantothenic Acid (Vitamin B5)\u003cspan class=\"src\"\u003e(as d-Calcium Pantothenate)\u003c\/span\u003e\n\u003c\/td\u003e\n \u003ctd class=\"amt r\"\u003e25 mg\u003c\/td\u003e\n \u003ctd class=\"dv r\"\u003e500%\u003c\/td\u003e\n \u003c\/tr\u003e\n \u003ctr class=\"thick nodv\"\u003e\n \u003ctd\u003eBetaine Anhydrous TMG (Trimethylglycine)\u003c\/td\u003e\n \u003ctd class=\"amt r\"\u003e400 mg\u003c\/td\u003e\n \u003ctd class=\"dv r\"\u003e*\u003c\/td\u003e\n \u003c\/tr\u003e\n \u003c\/tbody\u003e\n \u003c\/table\u003e\n \u003cp class=\"pfoot\"\u003e* No Daily Value (DV) established.\u003c\/p\u003e\n \u003cp class=\"oi\"\u003e\u003cstrong\u003eOther Ingredients:\u003c\/strong\u003e Vegetarian Capsule (Hypromellose, Purified Water), Vegetarian Magnesium Stearate.\u003c\/p\u003e\n \u003c\/div\u003e\n \u003c\/div\u003e\n \u003cp class=\"ioh-panel-cap\"\u003ePanel transcribed from the printed label, also shown in the product images. Percent Daily Values are based on a 2,000 calorie diet.\u003c\/p\u003e\n \u003c\/div\u003e\n\u003c\/section\u003e\n\n\u003c!-- ============ 8. QUAD ============ --\u003e\n\u003csection class=\"ioh-sec\"\u003e\n \u003cdiv class=\"ioh-wrap\"\u003e\n \u003cp class=\"ioh-eyebrow\"\u003eThe short version\u003c\/p\u003e\n \u003ch2\u003eIf you only read one section.\u003c\/h2\u003e\n \u003cdiv class=\"ioh-quad\"\u003e\n \u003cdiv class=\"ioh-qcell\"\u003e\n \u003cspan class=\"qh\"\u003eWhat it is\u003c\/span\u003e\n \u003cp\u003eA once-daily methylation support capsule built from active and coenzyme-form B vitamins — two folates, two B12s, P5P, riboflavin 5-phosphate, three thiamine forms — plus 400 mg of betaine anhydrous as a second methyl donor.\u003c\/p\u003e\n \u003cp\u003eThis is the concentrated tier of our methylation line, not the maintenance one: 2,000 mcg of folate and 1,500 mcg of B12 per capsule.\u003c\/p\u003e\n \u003cp\u003e30 vegetarian capsules. One month at one per day.\u003c\/p\u003e\n \u003c\/div\u003e\n \u003cdiv class=\"ioh-qcell\"\u003e\n \u003cspan class=\"qh\"\u003eWhat it does\u003c\/span\u003e\n \u003cp\u003eSupports the body's normal methylation and demethylation processes, and supports normal homocysteine metabolism.\u003c\/p\u003e\n \u003cp\u003eSupplies cofactors required for normal cellular energy production and supports healthy nervous system function.\u003c\/p\u003e\n \u003c\/div\u003e\n \u003cdiv class=\"ioh-qcell\"\u003e\n \u003cspan class=\"qh\"\u003eWho it's for\u003c\/span\u003e\n \u003cul\u003e\n \u003cli\u003eAnyone who has learned they carry an MTHFR variant and wants forms that don't depend on that conversion\u003c\/li\u003e\n \u003cli\u003ePeople who took a standard B complex and felt nothing\u003c\/li\u003e\n \u003cli\u003eAnyone tracking homocysteine with their physician\u003c\/li\u003e\n \u003cli\u003eVegetarians and vegans, who carry real B12 exposure\u003c\/li\u003e\n \u003cli\u003eAnyone who wants active forms without swallowing four capsules to get them\u003c\/li\u003e\n \u003c\/ul\u003e\n \u003c\/div\u003e\n \u003cdiv class=\"ioh-qcell\"\u003e\n \u003cspan class=\"qh\"\u003eHow to take it\u003c\/span\u003e\n \u003cp\u003eOne vegetarian capsule daily, with food. Earlier in the day suits most people better than late evening.\u003c\/p\u003e\n \u003cp\u003eIf you are new to methylated B vitamins or know you are sensitive to them, start with one capsule every other day for the first week and go daily from there.\u003c\/p\u003e\n \u003cp\u003eTake as directed by your healthcare practitioner.\u003c\/p\u003e\n \u003c\/div\u003e\n \u003c\/div\u003e\n \u003c\/div\u003e\n\u003c\/section\u003e\n\n\u003c!-- ============ 9. HONEST EXPECTATIONS ============ --\u003e\n\u003csection class=\"ioh-sec\"\u003e\n \u003cdiv class=\"ioh-wrap\"\u003e\n \u003cp class=\"ioh-eyebrow\"\u003eHonest expectations\u003c\/p\u003e\n \u003ch2\u003eWhat the first 90 days usually look like.\u003c\/h2\u003e\n \u003cp class=\"ioh-lead\"\u003eNo promises, no timelines. Methylation support mostly does its work where you can't feel it, and anyone who tells you otherwise is selling. Here is a realistic frame.\u003c\/p\u003e\n \u003cdiv class=\"ioh-tl\"\u003e\n \u003cdiv class=\"ioh-tlcard\"\u003e\n \u003cspan class=\"w\"\u003eWeeks 1 to 2 — Tolerance\u003c\/span\u003e\n \u003cp\u003eThe only thing you are looking for early on is whether it agrees with you. Most people notice nothing at all, which is the expected outcome. A minority who are sensitive to methyl donors notice they feel more alert or more wired than usual. If that happens, drop to every other day, or every third day, and talk to your practitioner. Feeling nothing is not a sign it isn't working.\u003c\/p\u003e\n \u003c\/div\u003e\n \u003cdiv class=\"ioh-tlcard\"\u003e\n \u003cspan class=\"w\"\u003eWeeks 3 to 6 — Steady state\u003c\/span\u003e\n \u003cp\u003eTissue levels of the B vitamins build gradually with consistent daily intake. If you were genuinely running short on any of these forms, this is the window in which people most often report a difference in day-to-day energy steadiness and mental clarity. Some people report nothing here either, and that is a legitimate result rather than a failure.\u003c\/p\u003e\n \u003c\/div\u003e\n \u003cdiv class=\"ioh-tlcard\"\u003e\n \u003cspan class=\"w\"\u003eDays 60 to 90 — Measure it\u003c\/span\u003e\n \u003cp\u003eThis is the honest answer to whether it is doing anything. Ask your physician for a homocysteine panel, and if you have a baseline from before you started, compare them. Methylation status is measurable, which means you do not have to rely on how you feel or on how convincing this page was. Numbers settle it.\u003c\/p\u003e\n \u003c\/div\u003e\n \u003c\/div\u003e\n \u003c\/div\u003e\n\u003c\/section\u003e\n\n\u003c!-- ============ 10. WHAT TO LOOK FOR ============ --\u003e\n\u003csection class=\"ioh-sec\"\u003e\n \u003cdiv class=\"ioh-wrap\"\u003e\n \u003cp class=\"ioh-eyebrow\"\u003eWhat to look for\u003c\/p\u003e\n \u003ch2\u003eHow to read any methylation label, including ours.\u003c\/h2\u003e\n \u003cp class=\"ioh-lead\"\u003eYou should not have to take our word for it. These are the specific lines to check on any B complex or methylation product before you buy it.\u003c\/p\u003e\n \u003cdiv class=\"ioh-cmp-scroll\"\u003e\n \u003ctable class=\"ioh-cmp\"\u003e\n \u003cthead\u003e\n \u003ctr\u003e\n \u003cth scope=\"col\"\u003eCheck this line\u003c\/th\u003e\n \u003cth scope=\"col\"\u003eTypical off-the-shelf B complex\u003c\/th\u003e\n \u003cth scope=\"col\" class=\"hl\"\u003eTMG Tri-Methyl Complex\u003c\/th\u003e\n \u003c\/tr\u003e\n \u003c\/thead\u003e\n \u003ctbody\u003e\n \u003ctr\u003e\n \u003cth scope=\"row\"\u003eFolate form\u003c\/th\u003e\n \u003ctd\u003eFolic acid\u003c\/td\u003e\n \u003ctd class=\"ours\"\u003eCalcium folinate plus crystalline L-5-MTHF calcium (Magnafolate C) — two forms\u003c\/td\u003e\n \u003c\/tr\u003e\n \u003ctr\u003e\n \u003cth scope=\"row\"\u003eB12 form\u003c\/th\u003e\n \u003ctd\u003eCyanocobalamin\u003c\/td\u003e\n \u003ctd class=\"ours\"\u003eMethylcobalamin plus adenosylcobalamin — both coenzyme forms\u003c\/td\u003e\n \u003c\/tr\u003e\n \u003ctr\u003e\n \u003cth scope=\"row\"\u003eB6 form\u003c\/th\u003e\n \u003ctd\u003ePyridoxine HCl only\u003c\/td\u003e\n \u003ctd class=\"ours\"\u003ePyridoxal 5-phosphate plus pyridoxine HCl\u003c\/td\u003e\n \u003c\/tr\u003e\n \u003ctr\u003e\n \u003cth scope=\"row\"\u003eB2 form\u003c\/th\u003e\n \u003ctd\u003eRiboflavin only\u003c\/td\u003e\n \u003ctd class=\"ours\"\u003eRiboflavin plus riboflavin 5-phosphate, the MTHFR cofactor\u003c\/td\u003e\n \u003c\/tr\u003e\n \u003ctr\u003e\n \u003cth scope=\"row\"\u003eB1 form\u003c\/th\u003e\n \u003ctd\u003eThiamine mononitrate\u003c\/td\u003e\n \u003ctd class=\"ours\"\u003eTTFD plus benfotiamine plus thiamine HCl — three forms\u003c\/td\u003e\n \u003c\/tr\u003e\n \u003ctr\u003e\n \u003cth scope=\"row\"\u003eSecond methyl-donor route\u003c\/th\u003e\n \u003ctd\u003eAbsent. The folate route is the only route supplied\u003c\/td\u003e\n \u003ctd class=\"ours\"\u003e400 mg betaine anhydrous, supplying the BHMT route\u003c\/td\u003e\n \u003c\/tr\u003e\n \u003ctr\u003e\n \u003cth scope=\"row\"\u003eDose disclosure\u003c\/th\u003e\n \u003ctd\u003eOften a proprietary blend with no individual amounts\u003c\/td\u003e\n \u003ctd class=\"ours\"\u003eEvery active listed at its dose, plus a published dose ledger\u003c\/td\u003e\n \u003c\/tr\u003e\n \u003ctr\u003e\n \u003cth scope=\"row\"\u003eDaily capsule load\u003c\/th\u003e\n \u003ctd\u003eTwo to four capsules per serving\u003c\/td\u003e\n \u003ctd class=\"ours\"\u003eOne capsule\u003c\/td\u003e\n \u003c\/tr\u003e\n \u003c\/tbody\u003e\n \u003c\/table\u003e\n \u003c\/div\u003e\n \u003c\/div\u003e\n\u003c\/section\u003e\n\n\u003c!-- ============ 11. PROOF, NOT PROMISES ============ --\u003e\n\u003csection class=\"ioh-sec\"\u003e\n \u003cdiv class=\"ioh-wrap\"\u003e\n \u003cp class=\"ioh-eyebrow\"\u003eProof, not promises\u003c\/p\u003e\n \u003ch2\u003eWhat we will stand behind in writing.\u003c\/h2\u003e\n \u003cp class=\"ioh-lead\"\u003eCount the forms on any other methylation label you own, then count them here. That comparison is the entire argument, and it is the one thing on this page we are willing to put in writing without a single qualifier.\u003c\/p\u003e\n \u003cdiv class=\"ioh-proof\"\u003e\n \u003cul class=\"ioh-checks\"\u003e\n \u003cli\u003eEight actives across fourteen distinct nutrient forms in one capsule, every one disclosed at its dose\u003c\/li\u003e\n \u003cli\u003eThree thiamine forms — TTFD, benfotiamine and thiamine HCl. Look for a second B-complex on the shelf that carries all three\u003c\/li\u003e\n \u003cli\u003eTwo folate forms and two B12 forms, split and declared individually rather than aggregated into one number\u003c\/li\u003e\n \u003cli\u003eZero folic acid. Zero cyanocobalamin. Not as a marketing line, as a formulation decision\u003c\/li\u003e\n \u003cli\u003eThe coenzyme form used wherever one exists, including riboflavin 5-phosphate, which most methylation formulas skip entirely despite MTHFR requiring riboflavin to function\u003c\/li\u003e\n \u003cli\u003eThe concentrated tier, not the maintenance tier: 2,000 mcg of folate and 1,500 mcg of B12 per capsule\u003c\/li\u003e\n \u003cli\u003eA published dose ledger naming the one ingredient that sits below its research range, printed before you buy rather than discovered afterward\u003c\/li\u003e\n \u003cli\u003eNo proprietary blends anywhere in the formula\u003c\/li\u003e\n \u003cli\u003eManufactured in an FDA-registered facility under current Good Manufacturing Practice, with testing at multiple stages of production\u003c\/li\u003e\n \u003cli\u003eOne capsule per day, so the label is honest about what a serving actually costs you to take\u003c\/li\u003e\n \u003c\/ul\u003e\n \u003cdiv class=\"ioh-shot\"\u003e\n \u003cimg src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/0711\/2228\/8923\/files\/TMG_Methyl_Complex_-_Supplement_Facts.png?v=1786976553\" alt=\"TMG Tri-Methyl Complex printed Supplement Facts panel showing all fourteen nutrient forms\"\u003e\n \u003cp class=\"cap\"\u003eThe printed panel, exactly as it ships. Fourteen nutrient forms, every amount declared, nothing aggregated and nothing hidden in a blend.\u003c\/p\u003e\n \u003c\/div\u003e\n \u003c\/div\u003e\n \u003c\/div\u003e\n\u003c\/section\u003e\n\n\u003c!-- ============ 12. QUALITY AND MANUFACTURING ============ --\u003e\n\u003csection class=\"ioh-sec\"\u003e\n \u003cdiv class=\"ioh-wrap\"\u003e\n \u003cp class=\"ioh-eyebrow\"\u003eManufacturing and standardization\u003c\/p\u003e\n \u003ch2\u003eWhere it is made and how it is controlled.\u003c\/h2\u003e\n \u003cdiv class=\"ioh-qual\"\u003e\n \u003cp\u003eWe are specific here rather than decorative, and we only claim what is documented for this product. If a line is not below, we are not claiming it.\u003c\/p\u003e\n \u003cdiv class=\"ioh-qgrid\"\u003e\n \u003cdiv class=\"ioh-qitem\"\u003e\n \u003cspan class=\"qt\"\u003eFacility\u003c\/span\u003e\n \u003cp\u003eManufactured in the United States in an FDA-registered facility operating under current Good Manufacturing Practice. FDA registers facilities; it does not approve dietary supplements, and we will not imply otherwise.\u003c\/p\u003e\n \u003c\/div\u003e\n \u003cdiv class=\"ioh-qitem\"\u003e\n \u003cspan class=\"qt\"\u003eRaw materials\u003c\/span\u003e\n \u003cp\u003eIdentified forms rather than generic vitamin names, including Magnafolate C crystalline L-5-MTHF calcium — a patented crystalline form selected for stability, since non-crystalline methylfolate degrades comparatively quickly.\u003c\/p\u003e\n \u003c\/div\u003e\n \u003cdiv class=\"ioh-qitem\"\u003e\n \u003cspan class=\"qt\"\u003eIn-process testing\u003c\/span\u003e\n \u003cp\u003eTesting is performed at multiple stages of production. If you want lot-specific documentation for the bottle you receive, contact us with the lot number and we will tell you exactly what exists for it.\u003c\/p\u003e\n \u003c\/div\u003e\n \u003c\/div\u003e\n \u003c\/div\u003e\n \u003c\/div\u003e\n\u003c\/section\u003e\n\n\u003c!-- ============ 13. PHYSICIAN AUTHORITY BAND ============ --\u003e\n\u003csection class=\"ioh-band\"\u003e\n \u003cdiv class=\"ioh-narrow\"\u003e\n \u003cp class=\"ioh-eyebrow on-dark\"\u003eFrom the founder\u003c\/p\u003e\n \u003cimg class=\"ioh-photo\" src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/0711\/2228\/8923\/files\/Men_s_Physique.png?v=1786637768\" alt=\"Dr. Andreas Boettcher on stage at a Master's Men's Physique competition\"\u003e\n \u003cp class=\"ioh-photo-cap\"\u003eDr. Andreas Boettcher. Photograph shown for context only and is not a product claim.\u003c\/p\u003e\n \u003cp class=\"pq\"\u003eI have spent 33 years watching patients bring me a B complex and ask why it did nothing. Most of the time the answer was not the dose. It was the form.\u003c\/p\u003e\n \u003cp\u003eMethylation is one of the few areas of functional medicine where the chemistry is genuinely settled enough to formulate against. We know which forms the enzymes bind. We know which cofactors those enzymes cannot run without. We know that riboflavin is required for MTHFR and that half the market ignores it. So we built this one out of the forms the body uses, dosed it as the concentrated tier rather than the maintenance one, and disclosed the single dose in the formula that sits below the published research range instead of hoping you would not check.\u003c\/p\u003e\n \u003cp\u003eThis is what I reach for when a patient tells me they carry an MTHFR variant and wants one capsule instead of five. I take it myself, and I retest my own homocysteine, because I would rather look at a number than at a label.\u003c\/p\u003e\n \u003cdiv class=\"ioh-badge\"\u003e\n \u003cimg src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/0711\/2228\/8923\/files\/IOH_Nutrition_Logo_eace362c-0f7a-433c-866c-910092695114.png?v=1785855378\" alt=\"IOH Nutrition\"\u003e\n \u003cp class=\"cred\"\u003eDr. Andreas Boettcher, B.S., D.C., C.F.M.P.\u003c\/p\u003e\n \u003cp class=\"founder\"\u003eFounder, It's Only Halftime\u003c\/p\u003e\n \u003cp class=\"acc\"\u003eIronman Triathlete  \/  Master's Men's Physique Competitor  \/  Medication-Free at 56  \/  33 Years of Clinical Practice\u003c\/p\u003e\n \u003c\/div\u003e\n \u003c\/div\u003e\n\u003c\/section\u003e\n\n\u003c!-- ============ 14. STACKS ============ --\u003e\n\u003csection class=\"ioh-sec\"\u003e\n \u003cdiv class=\"ioh-wrap\"\u003e\n \u003cp class=\"ioh-eyebrow\"\u003eStacks\u003c\/p\u003e\n \u003ch2\u003eWhat this pairs with, and why the pairing works.\u003c\/h2\u003e\n \u003cp class=\"ioh-lead\"\u003eA stack only earns its place if there is a mechanism behind it. Here is the reasoning for each one, and then the honest list of what you should not run alongside it.\u003c\/p\u003e\n \u003cdiv class=\"ioh-stacks\"\u003e\n\n \u003cdiv class=\"ioh-scard\"\u003e\n \u003cspan class=\"sk\"\u003eStack 01 — Reduce the demand\u003c\/span\u003e\n \u003ch3\u003ePure Creatine\u003c\/h3\u003e\n \u003cspan class=\"sprice\"\u003e$39.00\u003c\/span\u003e\n \u003cp\u003eLook back at the methyl budget. Creatine synthesis is the largest single line item on it, because the final step, GAMT, methylates guanidinoacetate using SAMe. When creatine arrives in the diet, your body builds less of its own, and the methyl groups that would have paid for it stay available for everything else on the list. This is the only pairing in the catalog that works on the demand side of methylation rather than the supply side, which makes it the most interesting stack we sell and the one almost nobody thinks to make.\u003c\/p\u003e\n \u003ca class=\"slink\" href=\"https:\/\/iohnutrition.com\/products\/pure-creatine\"\u003eView Pure Creatine\u003c\/a\u003e\n \u003c\/div\u003e\n\n \u003cdiv class=\"ioh-scard\"\u003e\n \u003cspan class=\"sk\"\u003eStack 02 — Finish the exit\u003c\/span\u003e\n \u003ch3\u003eNAC 90\u003c\/h3\u003e\n \u003cspan class=\"sprice\"\u003e$35.00\u003c\/span\u003e\n \u003cp\u003eNot all homocysteine should be recycled. Some of it needs to leave the cycle entirely, down the transsulfuration path, and the two enzymes that run that exit are both B6-dependent — which is what the 50 mg of P5P in this capsule is for. That path ends at cysteine, and cysteine is the rate-limiting input for the body's own glutathione production. NAC supplies cysteine directly. This capsule opens the exit; NAC supplies what the exit is for. If your interest in methylation is the detoxification side of it, this is the pairing.\u003c\/p\u003e\n \u003ca class=\"slink\" href=\"https:\/\/iohnutrition.com\/products\/nac-90-supports-respiratory-function-glutathione-production-detoxification\"\u003eView NAC 90\u003c\/a\u003e\n \u003c\/div\u003e\n\n \u003cdiv class=\"ioh-scard\"\u003e\n \u003cspan class=\"sk\"\u003eStack 03 — Supply the catalysts\u003c\/span\u003e\n \u003ch3\u003e5X Chelated Minerals\u003c\/h3\u003e\n \u003cspan class=\"sprice\"\u003e$48.00\u003c\/span\u003e\n \u003cp\u003eVitamins are the coenzymes. Minerals are the catalytic centers, and the enzymes on this page are full of them. BHMT, the enzyme that lets betaine donate its methyl group, is zinc-dependent. Methionine adenosyltransferase needs magnesium to build SAMe in the first place. Pyridoxal kinase needs zinc to keep B6 in its phosphorylated form. Perfect vitamin forms delivered into a mineral-short system still leave the reaction waiting, and that is a failure mode no B-complex label will ever warn you about.\u003c\/p\u003e\n \u003ca class=\"slink\" href=\"https:\/\/iohnutrition.com\/products\/5x-chelated-minerals-ultra-high-absorption-powder\"\u003eView 5X Chelated Minerals\u003c\/a\u003e\n \u003c\/div\u003e\n\n \u003c\/div\u003e\n\n \u003cdiv class=\"ioh-nodouble\"\u003e\n \u003cspan class=\"nh\"\u003eDo not double up — read this before you add anything\u003c\/span\u003e\n \u003cp\u003eMethylated B — B Vitamin Complex Plus is the maintenance tier of this same formula family. TMG Tri-Methyl Complex is the concentrated tier: roughly five times the folate, three times the B12 and four times the betaine, with the accessory ingredients stripped out. They are meant as a choice, not a pair. Running both puts vitamin B6 at 100 mg per day, which is the adult tolerable upper intake level from two bottles alone, and doubles your B1 and B2 as well. Pick one.\u003c\/p\u003e\n \u003cp\u003eThe same caution applies to Daily Multi, which already carries methylation support including methylated folate and B12. It is not dangerous alongside this, but it is duplicative, and it puts your real total higher than either label suggests on its own. Homocysteine Resist is also a methylation product in a different delivery form, so the same arithmetic applies.\u003c\/p\u003e\n \u003cp\u003eIf you have a reason to want more than one of these, that is a conversation to have with your physician with your labs in front of you, not a decision to make from a product page.\u003c\/p\u003e\n \u003c\/div\u003e\n \u003c\/div\u003e\n\u003c\/section\u003e\n\n\u003c!-- ============ 15. SIGN-OFF ============ --\u003e\n\u003csection class=\"ioh-signoff\"\u003e\n \u003cp class=\"line\"\u003eI would rather hand you a formula built out of the forms your body actually uses and tell you exactly where one dose falls short, than hand you a prettier label and let you find out later.\u003c\/p\u003e\n \u003cp class=\"stay\"\u003eStay Strong,\u003c\/p\u003e\n \u003cp class=\"sig\"\u003eDr. Andreas\u003c\/p\u003e\n \u003cp class=\"sigcred\"\u003eDr. Andreas Boettcher, B.S., D.C., C.F.M.P.\u003c\/p\u003e\n\u003c\/section\u003e\n\n\u003c!-- ============ 16. FAQ ============ --\u003e\n\u003csection class=\"ioh-sec\"\u003e\n \u003cdiv class=\"ioh-wrap\"\u003e\n \u003cp class=\"ioh-eyebrow\"\u003eFAQ\u003c\/p\u003e\n \u003ch2\u003eQuestions, answered.\u003c\/h2\u003e\n \u003cdiv class=\"ioh-faq\"\u003e\n\n \u003cdetails\u003e\n \u003csummary\u003eDo I need a genetic test before taking this?\u003c\/summary\u003e\n \u003cdiv class=\"ioh-ans\"\u003e\n \u003cp\u003eNo. Knowing your MTHFR status is interesting, and if you already have it from a panel or a consumer genetics report, it explains why active forms may suit you better. But the forms in this capsule are the forms the body uses regardless of your genotype. Nobody has to convert methylfolate into methylfolate.\u003c\/p\u003e\n \u003cp\u003eIf you want an actual measurement of how your methylation cycle is running, homocysteine is a more useful and far cheaper test than genotyping, and your physician can order it.\u003c\/p\u003e\n \u003c\/div\u003e\n \u003c\/details\u003e\n\n \u003cdetails\u003e\n \u003csummary\u003eThe percent Daily Values are enormous. Is that a problem?\u003c\/summary\u003e\n \u003cdiv class=\"ioh-ans\"\u003e\n \u003cp\u003eThey look dramatic because the Daily Values for B vitamins are set at the amount needed to prevent frank deficiency, which is a very low bar. B12's Daily Value is 2.4 mcg, so any meaningful oral B12 dose produces a five-figure percentage. That is arithmetic, not aggression.\u003c\/p\u003e\n \u003cp\u003eThe B vitamins here are water soluble or, in B12's case, poorly absorbed orally by design, and excess is largely excreted. The two amounts worth a real conversation are the folate at 3,400 mcg DFE and the B6 at 50 mg. Both are covered in the medication and safety question below, and both are reasons to have your practitioner in the loop rather than reasons to avoid the product.\u003c\/p\u003e\n \u003c\/div\u003e\n \u003c\/details\u003e\n\n \u003cdetails\u003e\n \u003csummary\u003eI have heard methylated B vitamins can make some people feel wired or irritable. Is that real?\u003c\/summary\u003e\n \u003cdiv class=\"ioh-ans\"\u003e\n \u003cp\u003eSome people do report it, and we would rather say so than pretend it never happens. It is not universal and it is not dangerous, but if you are one of the people who is sensitive to methyl donors, a full daily capsule from day one can feel like too much too fast.\u003c\/p\u003e\n \u003cp\u003eThe practical approach is to start with one capsule every other day for the first week, take it in the morning rather than the evening, and move to daily if it sits well. If it consistently does not, stop and talk to your practitioner. Methylation support is not a more-is-better situation.\u003c\/p\u003e\n \u003c\/div\u003e\n \u003c\/details\u003e\n\n \u003cdetails\u003e\n \u003csummary\u003eWhy two forms of folate and two forms of B12 instead of just the methylated ones?\u003c\/summary\u003e\n \u003cdiv class=\"ioh-ans\"\u003e\n \u003cp\u003eBecause methylfolate alone does not cover the whole folate pool. L-5-methylfolate is the methyl-donating form used in the methylation cycle, but folate also does work in DNA synthesis and repair that runs through other folate species. Folinic acid enters upstream and feeds those.\u003c\/p\u003e\n \u003cp\u003eSame logic on B12. Methylcobalamin is the cytosolic cofactor for the methylation cycle. Adenosylcobalamin is the mitochondrial form used in energy metabolism. They are not interchangeable, and a product that carries only one is covering half the job.\u003c\/p\u003e\n \u003c\/div\u003e\n \u003c\/details\u003e\n\n \u003cdetails\u003e\n \u003csummary\u003eIs 400 mg of TMG a full betaine dose?\u003c\/summary\u003e\n \u003cdiv class=\"ioh-ans\"\u003e\n \u003cp\u003eNo, and we say so on the page above rather than burying it here. Published betaine research on homocysteine has largely used doses from several hundred milligrams up to several grams a day, with much of it clustered well above this amount. 400 mg supplies the betaine route rather than saturating it.\u003c\/p\u003e\n \u003cp\u003eWhat this formula does uniquely well is supply the cofactors for every exit out of the homocysteine pool in a single capsule, at the concentrated end of the dose range. If you want a betaine intake at the level the research uses, that is 1.5 to 3 grams a day and it belongs in a powder, not a capsule — 1.5 grams of betaine alone would fill roughly two capsules by itself. Talk to your practitioner about that separately. We would rather tell you where the line is than let the front label do the implying.\u003c\/p\u003e\n \u003c\/div\u003e\n \u003c\/details\u003e\n\n \u003cdetails\u003e\n \u003csummary\u003eHow is this different from Methylated B, and which one should I take?\u003c\/summary\u003e\n \u003cdiv class=\"ioh-ans\"\u003e\n \u003cp\u003eSame formula family, two different tiers, and you take one or the other rather than both.\u003c\/p\u003e\n \u003cp\u003eMethylated B is the maintenance version. It covers more ground — it adds niacinamide, choline, pantethine and alpha lipoic acid — at daily-maintenance doses: 400 mcg of folate, 500 mcg of B12, 100 mg of betaine. That is the right bottle if you want broad daily coverage of the B family in good forms.\u003c\/p\u003e\n \u003cp\u003eTMG Tri-Methyl Complex is the concentrated version. It strips the accessory ingredients and raises the three that matter most for methylation: roughly five times the folate, three times the B12, four times the betaine. That is the right bottle if you have a homocysteine number you and your physician are watching, if the maintenance formula did not move it, or if you specifically want the higher folate and B12 without the extras.\u003c\/p\u003e\n \u003cp\u003eDo not stack them. Between the two, vitamin B6 would total 100 mg per day, which is the adult upper intake level from two bottles alone.\u003c\/p\u003e\n \u003c\/div\u003e\n \u003c\/details\u003e\n\n \u003cdetails\u003e\n \u003csummary\u003eCan I take this alongside my multivitamin?\u003c\/summary\u003e\n \u003cdiv class=\"ioh-ans\"\u003e\n \u003cp\u003eRead the panel first. Most multivitamins already contain folate, B12 and B6, and stacking them means the real total is higher than either label suggests. That matters most for B6, where the adult tolerable upper intake level is 100 mg per day and this capsule already supplies 50 mg.\u003c\/p\u003e\n \u003cp\u003eSpecifically within our own line: do not run this alongside Methylated B, Daily Multi or Homocysteine Resist. All three carry methylation support, and Methylated B is the maintenance version of this same formula. See the note in the stacks section above.\u003c\/p\u003e\n \u003cp\u003eAdd up the B6 across everything you take, including any protein powder or energy product. If the total lands near or above 100 mg per day, bring the list to your practitioner before continuing.\u003c\/p\u003e\n \u003c\/div\u003e\n \u003c\/details\u003e\n\n \u003cdetails\u003e\n \u003csummary\u003eMedications and safety — what should I check before taking this?\u003c\/summary\u003e\n \u003cdiv class=\"ioh-ans\"\u003e\n \u003cp\u003eThis formula contains clinically relevant amounts of folate, B12 and B6, and those three interact with real medications. Talk to your physician or pharmacist before starting if any of the following apply to you.\u003c\/p\u003e\n \u003cul\u003e\n \u003cli\u003eMethotrexate. It works by interfering with folate metabolism, and supplemental folate — including folinic acid, which is closely related to a drug used specifically to rescue methotrexate toxicity — can interact with how it works. This applies whether you take it for an autoimmune condition or in oncology. Do not add this product without your prescriber's direction.\u003c\/li\u003e\n \u003cli\u003eFluorouracil or capecitabine. Folinic acid is used clinically alongside these agents, which means supplemental folate is not a neutral background variable. Prescriber direction only.\u003c\/li\u003e\n \u003cli\u003eAnticonvulsants, including phenytoin, phenobarbital, primidone and valproate. Folate and these drugs affect each other in both directions, and folate supplementation can influence drug levels.\u003c\/li\u003e\n \u003cli\u003eLevodopa taken without carbidopa. Vitamin B6 at the amount in this capsule can affect how levodopa is handled. If you take a combination product, discuss it anyway.\u003c\/li\u003e\n \u003cli\u003eSulfasalazine, pyrimethamine, trimethoprim and other folate-antagonist drugs.\u003c\/li\u003e\n \u003cli\u003eMetformin and long-term acid-reducing medication. These affect B12 status, which is a reason your practitioner may want to know you are supplementing rather than a reason to avoid it.\u003c\/li\u003e\n \u003c\/ul\u003e\n \u003cp\u003eTwo more things worth saying plainly. High-dose folate can mask the blood picture of a B12 deficiency; this formula includes substantial B12 alongside it, which is the correct design, but it is still a reason to have your levels looked at rather than guessed at. And long-term high-dose vitamin B6 has been associated with peripheral nerve effects, generally at intakes well above the amount here — 50 mg per capsule sits below the 100 mg adult upper intake level, but this is not a product to take indefinitely without your practitioner reviewing it.\u003c\/p\u003e\n \u003cp\u003eIf you are pregnant, nursing, planning a pregnancy, or managing any diagnosed condition, talk to your physician before use. That is not boilerplate here. Folate intake during pregnancy is something your prescriber should be actively directing.\u003c\/p\u003e\n \u003c\/div\u003e\n \u003c\/details\u003e\n\n \u003cdetails\u003e\n \u003csummary\u003eWhen should I take it, and does it need food?\u003c\/summary\u003e\n \u003cdiv class=\"ioh-ans\"\u003e\n \u003cp\u003eOne capsule daily with food. Food is not strictly required but it improves tolerance for most people. Earlier in the day tends to suit people better than late evening, particularly anyone who notices methyl donors making them feel more alert.\u003c\/p\u003e\n \u003c\/div\u003e\n \u003c\/details\u003e\n\n \u003cdetails\u003e\n \u003csummary\u003eIs it vegetarian? Any allergens?\u003c\/summary\u003e\n \u003cdiv class=\"ioh-ans\"\u003e\n \u003cp\u003eThe capsule is hypromellose, a plant-derived vegetarian capsule, and the only other excipient is vegetarian magnesium stearate. There are 30 vegetarian capsules per bottle. The full other-ingredients line appears on the panel above and on the printed label in the product images.\u003c\/p\u003e\n \u003c\/div\u003e\n \u003c\/details\u003e\n\n \u003cdetails\u003e\n \u003csummary\u003eHow will I know whether it is working?\u003c\/summary\u003e\n \u003cdiv class=\"ioh-ans\"\u003e\n \u003cp\u003eMeasure it. Ask your physician for a homocysteine level, ideally before you start and again after two to three months. Methylation is one of the few things in this category with a straightforward, inexpensive marker, which means you do not have to rely on how you feel or on how persuasive this page was.\u003c\/p\u003e\n \u003c\/div\u003e\n \u003c\/details\u003e\n\n \u003c\/div\u003e\n \u003c\/div\u003e\n\u003c\/section\u003e\n\n\u003c!-- ============ 17. CLOSE BAND ============ --\u003e\n\u003csection class=\"ioh-close\"\u003e\n \u003cp class=\"kicker\"\u003eThe bottom line\u003c\/p\u003e\n \u003ch2\u003eYour cells do not care what the label says. They care what form arrived.\u003c\/h2\u003e\n \u003cp\u003eEvery methylation product on the shelf lists roughly the same eight nutrients. Almost none carry fourteen forms of them in a single capsule, and almost none tell you which form, which dose, or what the methyl groups you are buying are actually going to be spent on. We showed you the budget, we supplied it in forms that do not wait on a conversion step, and we told you the one number in the formula that sits below the research range instead of hoping you would not look.\u003c\/p\u003e\n \u003cp\u003eTake it for ninety days. Then have your homocysteine measured, and let the number decide whether we earned it.\u003c\/p\u003e\n\u003c\/section\u003e\n\n\u003c!-- ============ 18. FOOTER ============ --\u003e\n\u003cdiv class=\"ioh-footer\"\u003e\n \u003cp\u003eMagnafolate® is a registered trademark of Lianyungang Jinkang Hexin Pharmaceutical Co., Ltd.\u003c\/p\u003e\n \u003cp\u003eManufactured in the United States in an FDA-registered facility operating under current Good Manufacturing Practice. FDA registers manufacturing facilities; it does not approve dietary supplements. Testing is performed at multiple stages of production. We use high-quality raw materials and identify the specific nutrient forms used rather than generic vitamin names.\u003c\/p\u003e\n \u003cp\u003eKeep out of reach of children. Do not use if the safety seal is broken. Store in a cool, dry place. Consult your physician before use if you are pregnant, nursing, planning a pregnancy, taking any medication, or managing a diagnosed medical condition.\u003c\/p\u003e\n \u003cp class=\"disc\"\u003eThese statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.\u003c\/p\u003e\n\u003c\/div\u003e\n\n\u003c\/div\u003e","brand":"IOH Nutrition LLC","offers":[{"title":"Default Title","offer_id":53393225875739,"sku":"C210IOH","price":32.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0711\/2228\/8923\/files\/TMG_Methyl_Complex_-_MTHFR_Support.png?v=1786976554","url":"https:\/\/iohnutrition.com\/products\/tmg-tri-methyl-complex-for-powerful-methylation-support","provider":"IOH Nutrition LLC","version":"1.0","type":"link"}